Please use this identifier to cite or link to this item:
|Title:||Platelet serotonin uptake and 3H-imipramine binding in panic disorder.||Austin Authors:||Norman, Trevor R ;Sartor, Daniela M;Judd, F K;Burrows, Graham D;Gregory, M S;McIntyre, I M||Affiliation:||Department of Psychiatry, University of Melbourne, Austin Hospital, Victoria, Australia||Issue Date:||8-Jul-1989||Publication information:||Journal of Affective Disorders; 17(1): 77-81||Abstract:||Platelet serotonin uptake and 3H-imipramine binding were measured in eight patients with panic disorders and nine controls. The Vmax of serotonin uptake was significantly elevated in patients compared to controls (77 +/- 14 vs. 50 +/- 4 pmol/10(8) platelets/min; P less than 0.05) while Km values were not different (1.46 +/- 0.41 vs. 1.24 +/- 0.20 microM). 3H-Imipramine binding to ruptured platelet membranes was not significantly different between patients and controls for either Bmax (395 +/- 71 vs. 412 +/- 107 fmol/mg protein) or Kd (0.90 +/- 0.18 vs. 1.09 +/- 0.30 nM). The implications for a serotonergic dysfunction in panic disorders are discussed.||Gov't Doc #:||2544638||URI:||http://ahro.austin.org.au/austinjspui/handle/1/12511||URL:||https://pubmed.ncbi.nlm.nih.gov/2544638||Type:||Journal Article||Subjects:||Adult
|Appears in Collections:||Journal articles|
Show full item record
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.