Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12511
Title: Platelet serotonin uptake and 3H-imipramine binding in panic disorder.
Austin Authors: Norman, Trevor R ;Sartor, Daniela M;Judd, F K;Burrows, Graham D;Gregory, M S;McIntyre, I M
Affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Victoria, Australia
Issue Date: 8-Jul-1989
Publication information: Journal of Affective Disorders; 17(1): 77-81
Abstract: Platelet serotonin uptake and 3H-imipramine binding were measured in eight patients with panic disorders and nine controls. The Vmax of serotonin uptake was significantly elevated in patients compared to controls (77 +/- 14 vs. 50 +/- 4 pmol/10(8) platelets/min; P less than 0.05) while Km values were not different (1.46 +/- 0.41 vs. 1.24 +/- 0.20 microM). 3H-Imipramine binding to ruptured platelet membranes was not significantly different between patients and controls for either Bmax (395 +/- 71 vs. 412 +/- 107 fmol/mg protein) or Kd (0.90 +/- 0.18 vs. 1.09 +/- 0.30 nM). The implications for a serotonergic dysfunction in panic disorders are discussed.
Gov't Doc #: 2544638
URI: https://ahro.austin.org.au/austinjspui/handle/1/12511
Journal: Journal of affective disorders
URL: https://pubmed.ncbi.nlm.nih.gov/2544638
Type: Journal Article
Subjects: Adult
Agoraphobia.blood
Blood Platelets.metabolism
Carrier Proteins
Fear.physiology
Female
Humans
Imipramine.pharmacokinetics
Male
Panic.physiology
Phobic Disorders.blood
Receptors, Drug
Receptors, Neurotransmitter.metabolism
Serotonin.blood
Appears in Collections:Journal articles

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