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Title: Higher serum undercarboxylated osteocalcin and other bone turnover markers are associated with reduced diabetes risk and lower estradiol concentrations in older men.
Austin Authors: Yeap, Bu B;Alfonso, Helman;Chubb, S A Paul;Gauci, Richard;Byrnes, Elizabeth;Beilby, John P;Ebeling, Peter R;Handelsman, David J;Allan, Carolyn A;Grossmann, Mathis ;Norman, Paul E;Flicker, Leon
Affiliation: Monash Institute of Medical Research (C.A.A.), Prince Henry's Research Institute, Melbourne, Victoria 3168, Australia
Department of Endocrinology and Diabetes (B.B.Y., R.G.), Fremantle and Fiona Stanley Hospitals, Perth, Western Australia 6160, Australia
School of Public Health (H.A.), Curtin University, Perth, Western Australia 6102, Australia
PathWest Laboratory Medicine (S.A.P.C., J.P.B.), Fremantle, Royal Perth and Sir Charles Gairdner Hospitals, Perth, Western Australia 6160, Australia
Department of Medicine (P.R.E.), School for Clinical Sciences, Monash University, Melbourne, Victoria 3800, Australia
ANZAC Research Institute (D.J.H.), University of Sydney, Sydney, New South Wales 2139, Australia
and Department of Medicine (M.G.), Austin Health, University of Melbourne, Melbourne, Victoria, 3084 Australia
Schools of Medicine and Pharmacology (B.B.Y., S.A.P.C., L.F.) and Surgery (P.E.N.) and Western Australian Centre for Health and Ageing (L.F.), Centre for Medical Research, University of Western Australia, Perth, Western Australia 6009, Australia
Issue Date: 1-Jan-2015
Publication information: The Journal of Clinical Endocrinology and Metabolism; 100(1): 63-71
Abstract: In mice, undercarboxylated osteocalcin (ucOC) modulates insulin secretion and sensitivity and increases testosterone (T) secretion from Leydig cells, but human data are lacking. We hypothesized that ucOC is associated with diabetes risk and modulates sex hormone concentrations in older men, distinct from other bone turnover markers.PARTICIPANTS were community-dwelling men aged 70 to 89 years resident in Perth, Western Australia.Serum total osteocalcin (TOC), N-terminal propeptide of type I collagen (P1NP), and collagen type I C-terminal cross-linked telopeptide (CTX) were measured by immunoassay, and ucOC by hydroxyapatite binding. Plasma total T, DHT, and estradiol (E2) were assayed by mass spectrometry.Excluding men with osteoporosis or conditions affecting sex hormones or on bisphosphonates, glucocorticoids, or warfarin, 2966 men were included. In multivariate analyses, higher ucOC was associated with reduced diabetes risk (odds ratio [OR] per 1 SD increase = 0.55, P < .001). Similar results were seen for TOC (OR = 0.60, P < .001), P1NP (OR = 0.64, P < .001), and CTX (OR = 0.60, P < .001) but not ucOC/TOC. When all 4 markers were included in the fully adjusted model, higher ucOC (OR = 0.56, P < .001) and CTX (OR = 0.76, P = .008) remained associated with reduced diabetes risk. E2 was inversely associated with ucOC (coefficient -0.04, P = .031), TOC (-0.05, P = .001) and CTX (-0.04, P = .016); and positively with ucOC/TOC (0.05, P = .002). DHT was inversely associated with ucOC/TOC (-0.04, P = .040). T was not associated with bone turnover.Higher bone remodeling rates are associated with reduced diabetes risk in older men. Higher ucOC is both a marker of bone remodeling and an independent predictor of reduced diabetes risk. E2 is inversely associated with bone turnover markers. We found no evidence ucOC modulates circulating T in older men.
Gov't Doc #: 25365314
DOI: 10.1210/jc.2014-3019
Journal: The Journal of Clinical Endocrinology and Metabolism
Type: Journal Article
Appears in Collections:Journal articles

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