Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12457
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dc.contributor.authorYeap, Bu Ben
dc.contributor.authorAlfonso, Helmanen
dc.contributor.authorChubb, S A Paulen
dc.contributor.authorGauci, Richarden
dc.contributor.authorByrnes, Elizabethen
dc.contributor.authorBeilby, John Pen
dc.contributor.authorEbeling, Peter Ren
dc.contributor.authorHandelsman, David Jen
dc.contributor.authorAllan, Carolyn Aen
dc.contributor.authorGrossmann, Mathisen
dc.contributor.authorNorman, Paul Een
dc.contributor.authorFlicker, Leonen
dc.date.accessioned2015-05-16T02:09:29Z
dc.date.available2015-05-16T02:09:29Z
dc.date.issued2015-01-01en
dc.identifier.citationThe Journal of Clinical Endocrinology and Metabolism; 100(1): 63-71en
dc.identifier.govdoc25365314en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12457en
dc.description.abstractIn mice, undercarboxylated osteocalcin (ucOC) modulates insulin secretion and sensitivity and increases testosterone (T) secretion from Leydig cells, but human data are lacking. We hypothesized that ucOC is associated with diabetes risk and modulates sex hormone concentrations in older men, distinct from other bone turnover markers.PARTICIPANTS were community-dwelling men aged 70 to 89 years resident in Perth, Western Australia.Serum total osteocalcin (TOC), N-terminal propeptide of type I collagen (P1NP), and collagen type I C-terminal cross-linked telopeptide (CTX) were measured by immunoassay, and ucOC by hydroxyapatite binding. Plasma total T, DHT, and estradiol (E2) were assayed by mass spectrometry.Excluding men with osteoporosis or conditions affecting sex hormones or on bisphosphonates, glucocorticoids, or warfarin, 2966 men were included. In multivariate analyses, higher ucOC was associated with reduced diabetes risk (odds ratio [OR] per 1 SD increase = 0.55, P < .001). Similar results were seen for TOC (OR = 0.60, P < .001), P1NP (OR = 0.64, P < .001), and CTX (OR = 0.60, P < .001) but not ucOC/TOC. When all 4 markers were included in the fully adjusted model, higher ucOC (OR = 0.56, P < .001) and CTX (OR = 0.76, P = .008) remained associated with reduced diabetes risk. E2 was inversely associated with ucOC (coefficient -0.04, P = .031), TOC (-0.05, P = .001) and CTX (-0.04, P = .016); and positively with ucOC/TOC (0.05, P = .002). DHT was inversely associated with ucOC/TOC (-0.04, P = .040). T was not associated with bone turnover.Higher bone remodeling rates are associated with reduced diabetes risk in older men. Higher ucOC is both a marker of bone remodeling and an independent predictor of reduced diabetes risk. E2 is inversely associated with bone turnover markers. We found no evidence ucOC modulates circulating T in older men.en
dc.language.isoenen
dc.titleHigher serum undercarboxylated osteocalcin and other bone turnover markers are associated with reduced diabetes risk and lower estradiol concentrations in older men.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe Journal of Clinical Endocrinology and Metabolismen
dc.identifier.affiliationMonash Institute of Medical Research (C.A.A.), Prince Henry's Research Institute, Melbourne, Victoria 3168, Australiaen
dc.identifier.affiliationDepartment of Endocrinology and Diabetes (B.B.Y., R.G.), Fremantle and Fiona Stanley Hospitals, Perth, Western Australia 6160, Australiaen
dc.identifier.affiliationSchool of Public Health (H.A.), Curtin University, Perth, Western Australia 6102, Australiaen
dc.identifier.affiliationPathWest Laboratory Medicine (S.A.P.C., J.P.B.), Fremantle, Royal Perth and Sir Charles Gairdner Hospitals, Perth, Western Australia 6160, Australiaen
dc.identifier.affiliationDepartment of Medicine (P.R.E.), School for Clinical Sciences, Monash University, Melbourne, Victoria 3800, Australiaen
dc.identifier.affiliationANZAC Research Institute (D.J.H.), University of Sydney, Sydney, New South Wales 2139, Australiaen
dc.identifier.affiliationand Department of Medicine (M.G.), Austin Health, University of Melbourne, Melbourne, Victoria, 3084 Australiaen
dc.identifier.affiliationSchools of Medicine and Pharmacology (B.B.Y., S.A.P.C., L.F.) and Surgery (P.E.N.) and Western Australian Centre for Health and Ageing (L.F.), Centre for Medical Research, University of Western Australia, Perth, Western Australia 6009, Australiaen
dc.identifier.doi10.1210/jc.2014-3019en
dc.description.pages63-71en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/25365314en
dc.type.austinJournal Articleen
local.name.researcherGrossmann, Mathis
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEndocrinology-
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