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Title: Intermittent diabetic microalbuminuria: association with blood pressure, glycemic control, and protein intake.
Austin Authors: Cooper, Mark E;O'Brien, R C;Murray, R M;Seeman, Ego ;Jerums, George 
Affiliation: Department of Medicine, Austin Hospital, University of Melbourne, Victoria, Australia
Issue Date: 6-Apr-1989
Publication information: The Journal of Diabetic Complications; 3(2): 92-8
Abstract: The factors associated with intermittent microalbuminuria were studied over 7 years in 49 Type I and 53 Type II diabetics who had normal initial albumin clearance. Fasting plasma glucose, HbA1, 24 hour urinary glucose, blood pressure, protein intake (24 hour urinary urea), and the renal clearance of albumin, transferrin, and IgG, as well as total proteinuria, were assessed every 3-6 months. Fifteen Type I and 11 Type II diabetics had 40 and 31 episodes, respectively, of intermittent microalbuminuria, defined as an albumin clearance greater than 11 nl/sec, without progressing to persistent microalbuminuria. Rises in transferrin and IgG clearance paralleled albumin clearance in both Type I and Type II diabetics. There were no significant changes in blood pressure or glycemic control during episodes of intermittent microalbuminuria. However, in Type I diabetics, intermittent microalbuminuria was associated with higher levels of urinary urea excretion. This study raises the possibility that increased protein intake may participate in the development of nephropathy in Type I diabetes.
Gov't Doc #: 2526146
Type: Journal Article
Subjects: Adult
Blood Glucose.metabolism
Blood Pressure
Cohort Studies
Diabetes Mellitus, Type 1.blood.physiopathology.urine
Diabetes Mellitus, Type 2.blood.physiopathology.urine
Dietary Proteins
Follow-Up Studies
Hemoglobin A, Glycosylated.analysis
Immunoglobulin G.urine
Appears in Collections:Journal articles

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