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Title: Efficacy and safety of oral methazolamide in patients with type 2 diabetes: a 24-week, placebo-controlled, double-blind study.
Austin Authors: Simpson, Richard W;Nicholson, Geoffrey C;Proietto, Joseph ;Sarah, Alana;Sanders, Kerrie M;Phillips, Gabrielle;Chambers, Jo;MacGinley, Rob;Orford, Neil;Walder, Ken;Krippner, Guy;Skoff, Kathy;Wacher, Vincent J
Affiliation: Box Hill Hospital, Box Hill, Victoria, Australia
Heidelberg Repatriation Hospital, University of Melbourne, Melbourne, Victoria, Australia
Deakin University, Geelong, Victoria, Australia
Clinical Trial Unit, Department of Medicine, Barwon Health, Geelong, Victoria, Australia
Department of Clinical and Biomedical Sciences, Geelong Hospital, University of Melbourne, Melbourne, Victoria, Australia
Verva Pharmaceuticals, Ltd., Southbank, Victoria, Australia
Department of Epidemiology and Preventive Medicine, Barwon Health/Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia
Issue Date: 14-Aug-2014
Publication information: Diabetes Care 2014; 37(11): 3121-3
Abstract: To evaluate the safety and efficacy of methazolamide as a potential therapy for type 2 diabetes.This double-blind, placebo-controlled study randomized 76 patients to oral methazolamide (40 mg b.i.d.) or placebo for 24 weeks. The primary efficacy end point for methazolamide treatment was a placebo-corrected reduction in HbA1c from baseline after 24 weeks (ΔHbA1c).Mean ± SD baseline HbA1c was 7.1 ± 0.7% (54 ± 5 mmol/mol; n = 37) and 7.4 ± 0.6% (57 ± 5 mmol/mol; n = 39) in the methazolamide and placebo groups, respectively. Methazolamide treatment was associated with a ΔHbA1c of -0.39% (95% CI -0.82, 0.04; P < 0.05) (-4.3 mmol/mol [-9.0, 0.4]), an increase in the proportion of patients achieving HbA1c ≤6.5% (48 mmol/mol) from 8 to 33%, a rapid reduction in alanine aminotransferase (∼10 units/L), and weight loss (2%) in metformin-cotreated patients.Methazolamide is the archetype for a new intervention in type 2 diabetes with clinical benefits beyond glucose control.
Gov't Doc #: 25125506
DOI: 10.2337/dc14-1038
Type: Journal Article
Subjects: Aged
Carbonic Anhydrase Inhibitors.adverse effects.therapeutic use
Diabetes Mellitus, Type 2.drug therapy
Double-Blind Method
Hemoglobin A, Glycosylated.analysis
Hypoglycemic Agents.therapeutic use
Metformin.therapeutic use
Methazolamide.adverse effects.therapeutic use
Middle Aged
Weight Loss.drug effects
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