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Title: | Diffusion-weighted imaging properties of uterine fibroids pre- and post-uterine fibroid embolisation. | Austin Authors: | Kirpalani, Anish;Chong, Jennifer;Yang, Natalie ;Jenkins, Sarah J;Nisenbaum, Rosane;Prabhudesai, Vikramaditya;Anthwal, Shalini;Colak, Errol | Affiliation: | Centre for Research on Inner City Health, the Keenan Research Centre in the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Dalla Lana School of Public Health, University of Toronto, 30 Bond Street, Toronto, ON M5B 1W8, Canada Department of Radiology, Memorial University of Newfoundland, St. John's, NL A1B 3V6, Canada Department of Radiology, Austin Health, Heidelberg, Victoria 3084, Australia Department of Medical Imaging, University of Toronto, St. Michael's Hospital, 30 Bond Street, 3CC, Toronto, ON M5B 1W8, Canada |
Issue Date: | 7-Jun-2014 | Publication information: | European Journal of Radiology 2014; 83(9): 1620-5 | Abstract: | To determine the change in apparent diffusion coefficient (ADC) of uterine fibroids following uterine fibroid embolisation (UFE), and if the ADC change correlates with either volume loss or degree of contrast enhancement post-UFE.This study was approved by our institutional review board with waiver of consent. The pelvic MRI examinations, including diffusion-weighted MRI (DWI) using 4 b-values, of 50 consecutive patients prior to and 6 months post-UFE were analyzed. The volume, ADC and amount of enhancement were calculated for each fibroid both pre- and post-UFE. The percent residual enhancement for each fibroid was categorized as either: no (0-1%) residual enhancement or residual (>1%) enhancement. Statistical analysis compared ADC, enhancement and volume for each fibroid pre- and post-UFE using paired t-tests and Pearson correlation coefficients.The mean ADC of all (n=88) fibroids pre-UFE was 1.30±0.20×10(-3)mm(2)/s, and increased to 1.68±0.24×10(-3)mm(2)/s post-UFE (p<0.0001). Lower pre-UFE ADC correlated with greater ADC change post-UFE (r=-0.50; p<0.0001). There was no correlation between ADC change and volume change post-UFE (r=0.07; p=0.59). However, fibroids with no residual enhancement post-UFE had larger ADC change than those with residual enhancement (p=0.003).The ADC of fibroids rises post-UFE. ADC change post-UFE is associated with the degree of loss of enhancement and may therefore be valuable in predicting response to treatment in pre-procedural counseling. | Gov't Doc #: | 24976500 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12281 | DOI: | 10.1016/j.ejrad.2014.05.031 | Journal: | European journal of radiology | URL: | https://pubmed.ncbi.nlm.nih.gov/24976500 | Type: | Journal Article | Subjects: | ADC Diffusion weighted imaging Embolization Fibroid MRI Adult Contrast Media.diagnostic use Diffusion Magnetic Resonance Imaging.methods Embolization, Therapeutic.methods Female Humans Image Enhancement.methods Leiomyoma.diagnosis.therapy Meglumine.analogs & derivatives.diagnostic use Middle Aged Organometallic Compounds.diagnostic use Treatment Outcome Uterine Neoplasms.diagnosis.therapy Uterus.pathology |
Appears in Collections: | Journal articles |
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