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Title: Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria.
Austin Authors: Dubois, Bruno;Feldman, Howard H;Jacova, Claudia;Hampel, Harald;Molinuevo, José Luis;Blennow, Kaj;DeKosky, Steven T;Gauthier, Serge;Selkoe, Dennis;Bateman, Randall;Cappa, Stefano;Crutch, Sebastian;Engelborghs, Sebastiaan;Frisoni, Giovanni B;Fox, Nick C;Galasko, Douglas;Habert, Marie-Odile;Jicha, Gregory A;Nordberg, Agneta;Pasquier, Florence;Rabinovici, Gil;Robert, Philippe;Rowe, Christopher C ;Salloway, Stephen;Sarazin, Marie;Epelbaum, Stéphane;de Souza, Leonardo C;Vellas, Bruno;Visser, Pieter J;Schneider, Lon;Stern, Yaakov;Scheltens, Philip;Cummings, Jeffrey L
Affiliation: Centre des Maladies Cognitives et Comportementales, Institut du Cerveau et de la Moelle épinière, Paris, France
Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK
FRACP, Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Melbourne, Victoria, Australia
McGill Center for Studies in Aging, Douglas Hospital, Montreal, Quebec, QC, Canada
UBC Division of Neurology, S152 UBC Hospital, BC, Canada
UCSF Memory & Aging Center, Department of Neurology, University of California, San Francisco, CA, USA
Division of Neurology, University of British Columbia and Vancouver Coastal Health, Vancouver, BC, Canada
Harvard Medical School Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA
Department of Neurology, University of Virginia, Charlottesville, VA, USA
Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, USA
Cognitive Neuroscience Division of the Taub Institute, Presbyterian Hospital, New York, NY, USA
Department of Psychiatry, Neurology, and Gerontology, Keck School of Medicine of USC, Los Angeles, CA, USA
Neurology and the Memory and Aging Program, Butler Hospital, Department of Neurology and Psychiatry, The Warren Alpert Medical School of Brown University, Providence, RI, USA
University of Kentucky Alzheimer's Disease Center, Lexington, KY, USA
Washington University School of Medicine, St Louis, Missouri, MO, USA
Reference Centre for Biological Markers of Dementia, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA), Middelheim and Hoge Beuken, Antwerp, Belgium
IRCCS Fatebenefratelli, Brescia, Italy; HUG Belle-Idée, bâtiment les Voirons, Chêne-Bourg, France.
Hopitaux Universitaires et Université de Genève, Geneva, Switzerland
BarcelonaBeta Brain Research Centre, Fundació Pasqual Maragall, Barcelona, Spain.
Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, IDIBAPS Hospital Clinici Universitari, Barcelona, Spain
Dementia Research Centre, National Hospital, London, UK
AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Médecine Nucléaire, Paris, France.
INSERM UMR, Paris, France
Université Paris 5, Paris, France.
Neurologie de la Mémoire et du Langage, Centre Hospitalier Sainte-Anne, Paris Cedex, France
CHRU, Clinique Neurologique, Hôpital Roger Salengro, Lille, France.
Université Lille Nord de France, Lille, France
Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Université Pierre et Marie Curie-Paris 6, AP-HP, Hôpital de la Salpêtrière, Paris, France
Université Pierre et Marie Curie-Paris 6, AP-HP, Hôpital de la Salpêtrière, Paris, France.
Université Pierre et Marie Curie-Paris 6, AP-HP, Hôpital de la Salpêtrière, Paris, France
Department of Neurosciences, -University of California, San Diego, CA, USA
Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.
Vita-Salute San Raffaele University, Milan, Italy; Department of Clinical Neurosciences, Cognitive Neurorehabilitation, Milan, Italy.
Karolinska Institutet, Karolinska University Hospital Huddinge, Alzheimer Neurobiology Center, Stockholm, Sweden.
EA CoBTeK and Memory Center, CHU University of Nice, UNSA, Hôpital de Cimiez 4 av Victoria, Nice, France.
Gerontopole, Pavillon Junod, University Toulouse 3, Toulouse, France.
Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, Netherlands; Department of Neurology and Alzheimer Center, Amsterdam, Netherlands.
Alzheimer Centrum Vrije Universiteit Medical Center, VU University, Amsterdam, Netherlands.
Issue Date: 1-Jun-2014
Publication information: The Lancet. Neurology; 13(6): 614-29
Abstract: In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging-Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's disease (AD) that better define clinical phenotypes and integrate biomarkers into the diagnostic process, covering the full staging of the disease. This Position Paper considers the strengths and limitations of the IWG research diagnostic criteria and proposes advances to improve the diagnostic framework. On the basis of these refinements, the diagnosis of AD can be simplified, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological biomarker consistent with the presence of Alzheimer's pathology. We propose that downstream topographical biomarkers of the disease, such as volumetric MRI and fluorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease. This paper also elaborates on the specific diagnostic criteria for atypical forms of AD, for mixed AD, and for the preclinical states of AD.
Gov't Doc #: 24849862
DOI: 10.1016/S1474-4422(14)70090-0
Type: Journal Article
Subjects: Alzheimer Disease.diagnosis.genetics.physiopathology
Biological Markers.analysis.chemistry
International Cooperation
Practice Guidelines as Topic.standards
Societies, Medical.standards
Appears in Collections:Journal articles

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