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https://ahro.austin.org.au/austinjspui/handle/1/12223| Title: | Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria. | Austin Authors: | Dubois, Bruno;Feldman, Howard H;Jacova, Claudia;Hampel, Harald;Molinuevo, José Luis;Blennow, Kaj;DeKosky, Steven T;Gauthier, Serge;Selkoe, Dennis;Bateman, Randall;Cappa, Stefano;Crutch, Sebastian;Engelborghs, Sebastiaan;Frisoni, Giovanni B;Fox, Nick C;Galasko, Douglas;Habert, Marie-Odile;Jicha, Gregory A;Nordberg, Agneta;Pasquier, Florence;Rabinovici, Gil;Robert, Philippe;Rowe, Christopher C ;Salloway, Stephen;Sarazin, Marie;Epelbaum, Stéphane;de Souza, Leonardo C;Vellas, Bruno;Visser, Pieter J;Schneider, Lon;Stern, Yaakov;Scheltens, Philip;Cummings, Jeffrey L | Affiliation: | Centre des Maladies Cognitives et Comportementales, Institut du Cerveau et de la Moelle épinière, Paris, France Dementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UK FRACP, Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Melbourne, Victoria, Australia McGill Center for Studies in Aging, Douglas Hospital, Montreal, Quebec, QC, Canada UBC Division of Neurology, S152 UBC Hospital, BC, Canada UCSF Memory & Aging Center, Department of Neurology, University of California, San Francisco, CA, USA Division of Neurology, University of British Columbia and Vancouver Coastal Health, Vancouver, BC, Canada Harvard Medical School Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USA Department of Neurology, University of Virginia, Charlottesville, VA, USA Lou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, USA Cognitive Neuroscience Division of the Taub Institute, Presbyterian Hospital, New York, NY, USA Department of Psychiatry, Neurology, and Gerontology, Keck School of Medicine of USC, Los Angeles, CA, USA Neurology and the Memory and Aging Program, Butler Hospital, Department of Neurology and Psychiatry, The Warren Alpert Medical School of Brown University, Providence, RI, USA University of Kentucky Alzheimer's Disease Center, Lexington, KY, USA Washington University School of Medicine, St Louis, Missouri, MO, USA Reference Centre for Biological Markers of Dementia, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. Department of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA), Middelheim and Hoge Beuken, Antwerp, Belgium IRCCS Fatebenefratelli, Brescia, Italy; HUG Belle-Idée, bâtiment les Voirons, Chêne-Bourg, France. Hopitaux Universitaires et Université de Genève, Geneva, Switzerland BarcelonaBeta Brain Research Centre, Fundació Pasqual Maragall, Barcelona, Spain. Alzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, IDIBAPS Hospital Clinici Universitari, Barcelona, Spain Dementia Research Centre, National Hospital, London, UK AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Médecine Nucléaire, Paris, France. INSERM UMR, Paris, France Université Paris 5, Paris, France. Neurologie de la Mémoire et du Langage, Centre Hospitalier Sainte-Anne, Paris Cedex, France CHRU, Clinique Neurologique, Hôpital Roger Salengro, Lille, France. Université Lille Nord de France, Lille, France Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil. Université Pierre et Marie Curie-Paris 6, AP-HP, Hôpital de la Salpêtrière, Paris, France Université Pierre et Marie Curie-Paris 6, AP-HP, Hôpital de la Salpêtrière, Paris, France. Université Pierre et Marie Curie-Paris 6, AP-HP, Hôpital de la Salpêtrière, Paris, France Department of Neurosciences, -University of California, San Diego, CA, USA Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden. Vita-Salute San Raffaele University, Milan, Italy; Department of Clinical Neurosciences, Cognitive Neurorehabilitation, Milan, Italy. Karolinska Institutet, Karolinska University Hospital Huddinge, Alzheimer Neurobiology Center, Stockholm, Sweden. EA CoBTeK and Memory Center, CHU University of Nice, UNSA, Hôpital de Cimiez 4 av Victoria, Nice, France. Gerontopole, Pavillon Junod, University Toulouse 3, Toulouse, France. Department of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, Netherlands; Department of Neurology and Alzheimer Center, Amsterdam, Netherlands. Alzheimer Centrum Vrije Universiteit Medical Center, VU University, Amsterdam, Netherlands. |
Issue Date: | 1-Jun-2014 | Publication information: | The Lancet. Neurology; 13(6): 614-29 | Abstract: | In the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging-Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's disease (AD) that better define clinical phenotypes and integrate biomarkers into the diagnostic process, covering the full staging of the disease. This Position Paper considers the strengths and limitations of the IWG research diagnostic criteria and proposes advances to improve the diagnostic framework. On the basis of these refinements, the diagnosis of AD can be simplified, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological biomarker consistent with the presence of Alzheimer's pathology. We propose that downstream topographical biomarkers of the disease, such as volumetric MRI and fluorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease. This paper also elaborates on the specific diagnostic criteria for atypical forms of AD, for mixed AD, and for the preclinical states of AD. | Gov't Doc #: | 24849862 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/12223 | DOI: | 10.1016/S1474-4422(14)70090-0 | Journal: | The Lancet. Neurology | URL: | https://pubmed.ncbi.nlm.nih.gov/24849862 | Type: | Journal Article | Subjects: | Alzheimer Disease.diagnosis.genetics.physiopathology Biological Markers.analysis.chemistry Humans International Cooperation Phenotype Practice Guidelines as Topic.standards Societies, Medical.standards |
| Appears in Collections: | Journal articles |
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