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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/12223
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dc.contributor.authorDubois, Brunoen
dc.contributor.authorFeldman, Howard Hen
dc.contributor.authorJacova, Claudiaen
dc.contributor.authorHampel, Haralden
dc.contributor.authorMolinuevo, José Luisen
dc.contributor.authorBlennow, Kajen
dc.contributor.authorDeKosky, Steven Ten
dc.contributor.authorGauthier, Sergeen
dc.contributor.authorSelkoe, Dennisen
dc.contributor.authorBateman, Randallen
dc.contributor.authorCappa, Stefanoen
dc.contributor.authorCrutch, Sebastianen
dc.contributor.authorEngelborghs, Sebastiaanen
dc.contributor.authorFrisoni, Giovanni Ben
dc.contributor.authorFox, Nick Cen
dc.contributor.authorGalasko, Douglasen
dc.contributor.authorHabert, Marie-Odileen
dc.contributor.authorJicha, Gregory Aen
dc.contributor.authorNordberg, Agnetaen
dc.contributor.authorPasquier, Florenceen
dc.contributor.authorRabinovici, Gilen
dc.contributor.authorRobert, Philippeen
dc.contributor.authorRowe, Christopher Cen
dc.contributor.authorSalloway, Stephenen
dc.contributor.authorSarazin, Marieen
dc.contributor.authorEpelbaum, Stéphaneen
dc.contributor.authorde Souza, Leonardo Cen
dc.contributor.authorVellas, Brunoen
dc.contributor.authorVisser, Pieter Jen
dc.contributor.authorSchneider, Lonen
dc.contributor.authorStern, Yaakoven
dc.contributor.authorScheltens, Philipen
dc.contributor.authorCummings, Jeffrey Len
dc.date.accessioned2015-05-16T01:52:48Z
dc.date.available2015-05-16T01:52:48Z
dc.date.issued2014-06-01en
dc.identifier.citationThe Lancet. Neurology; 13(6): 614-29en
dc.identifier.govdoc24849862en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/12223en
dc.description.abstractIn the past 8 years, both the International Working Group (IWG) and the US National Institute on Aging-Alzheimer's Association have contributed criteria for the diagnosis of Alzheimer's disease (AD) that better define clinical phenotypes and integrate biomarkers into the diagnostic process, covering the full staging of the disease. This Position Paper considers the strengths and limitations of the IWG research diagnostic criteria and proposes advances to improve the diagnostic framework. On the basis of these refinements, the diagnosis of AD can be simplified, requiring the presence of an appropriate clinical AD phenotype (typical or atypical) and a pathophysiological biomarker consistent with the presence of Alzheimer's pathology. We propose that downstream topographical biomarkers of the disease, such as volumetric MRI and fluorodeoxyglucose PET, might better serve in the measurement and monitoring of the course of disease. This paper also elaborates on the specific diagnostic criteria for atypical forms of AD, for mixed AD, and for the preclinical states of AD.en
dc.language.isoenen
dc.subject.otherAlzheimer Disease.diagnosis.genetics.physiopathologyen
dc.subject.otherBiological Markers.analysis.chemistryen
dc.subject.otherHumansen
dc.subject.otherInternational Cooperationen
dc.subject.otherPhenotypeen
dc.subject.otherPractice Guidelines as Topic.standardsen
dc.subject.otherSocieties, Medical.standardsen
dc.titleAdvancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe Lancet. Neurologyen
dc.identifier.affiliationCentre des Maladies Cognitives et Comportementales, Institut du Cerveau et de la Moelle épinière, Paris, Franceen
dc.identifier.affiliationDementia Research Centre, Department of Neurodegeneration, Institute of Neurology, University College London, London, UKen
dc.identifier.affiliationFRACP, Department of Nuclear Medicine and Centre for PET, Austin Health, Heidelberg, Melbourne, Victoria, Australiaen
dc.identifier.affiliationMcGill Center for Studies in Aging, Douglas Hospital, Montreal, Quebec, QC, Canadaen
dc.identifier.affiliationUBC Division of Neurology, S152 UBC Hospital, BC, Canadaen
dc.identifier.affiliationUCSF Memory & Aging Center, Department of Neurology, University of California, San Francisco, CA, USAen
dc.identifier.affiliationDivision of Neurology, University of British Columbia and Vancouver Coastal Health, Vancouver, BC, Canadaen
dc.identifier.affiliationHarvard Medical School Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA, USAen
dc.identifier.affiliationDepartment of Neurology, University of Virginia, Charlottesville, VA, USAen
dc.identifier.affiliationLou Ruvo Center for Brain Health, Cleveland Clinic, Las Vegas, NV, USAen
dc.identifier.affiliationCognitive Neuroscience Division of the Taub Institute, Presbyterian Hospital, New York, NY, USAen
dc.identifier.affiliationDepartment of Psychiatry, Neurology, and Gerontology, Keck School of Medicine of USC, Los Angeles, CA, USAen
dc.identifier.affiliationNeurology and the Memory and Aging Program, Butler Hospital, Department of Neurology and Psychiatry, The Warren Alpert Medical School of Brown University, Providence, RI, USAen
dc.identifier.affiliationUniversity of Kentucky Alzheimer's Disease Center, Lexington, KY, USAen
dc.identifier.affiliationWashington University School of Medicine, St Louis, Missouri, MO, USAen
dc.identifier.affiliationReference Centre for Biological Markers of Dementia, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.en
dc.identifier.affiliationDepartment of Neurology and Memory Clinic, Hospital Network Antwerp (ZNA), Middelheim and Hoge Beuken, Antwerp, Belgiumen
dc.identifier.affiliationIRCCS Fatebenefratelli, Brescia, Italy; HUG Belle-Idée, bâtiment les Voirons, Chêne-Bourg, France.en
dc.identifier.affiliationHopitaux Universitaires et Université de Genève, Geneva, Switzerlanden
dc.identifier.affiliationBarcelonaBeta Brain Research Centre, Fundació Pasqual Maragall, Barcelona, Spain.en
dc.identifier.affiliationAlzheimer's Disease and Other Cognitive Disorders Unit, Neurology Service, IDIBAPS Hospital Clinici Universitari, Barcelona, Spainen
dc.identifier.affiliationDementia Research Centre, National Hospital, London, UKen
dc.identifier.affiliationAP-HP, Groupe Hospitalier Pitié-Salpêtrière, Service de Médecine Nucléaire, Paris, France.en
dc.identifier.affiliationINSERM UMR, Paris, Franceen
dc.identifier.affiliationUniversité Paris 5, Paris, France.en
dc.identifier.affiliationNeurologie de la Mémoire et du Langage, Centre Hospitalier Sainte-Anne, Paris Cedex, Franceen
dc.identifier.affiliationCHRU, Clinique Neurologique, Hôpital Roger Salengro, Lille, France.en
dc.identifier.affiliationUniversité Lille Nord de France, Lille, Franceen
dc.identifier.affiliationFaculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.en
dc.identifier.affiliationUniversité Pierre et Marie Curie-Paris 6, AP-HP, Hôpital de la Salpêtrière, Paris, Franceen
dc.identifier.affiliationUniversité Pierre et Marie Curie-Paris 6, AP-HP, Hôpital de la Salpêtrière, Paris, France.en
dc.identifier.affiliationUniversité Pierre et Marie Curie-Paris 6, AP-HP, Hôpital de la Salpêtrière, Paris, Franceen
dc.identifier.affiliationDepartment of Neurosciences, -University of California, San Diego, CA, USAen
dc.identifier.affiliationClinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital, Mölndal, Sweden.en
dc.identifier.affiliationVita-Salute San Raffaele University, Milan, Italy; Department of Clinical Neurosciences, Cognitive Neurorehabilitation, Milan, Italy.en
dc.identifier.affiliationKarolinska Institutet, Karolinska University Hospital Huddinge, Alzheimer Neurobiology Center, Stockholm, Sweden.en
dc.identifier.affiliationEA CoBTeK and Memory Center, CHU University of Nice, UNSA, Hôpital de Cimiez 4 av Victoria, Nice, France.en
dc.identifier.affiliationGerontopole, Pavillon Junod, University Toulouse 3, Toulouse, France.en
dc.identifier.affiliationDepartment of Psychiatry and Neuropsychology, Alzheimer Centre Limburg, School of Mental Health and Neuroscience, Maastricht University Medical Centre, Maastricht, Netherlands; Department of Neurology and Alzheimer Center, Amsterdam, Netherlands.en
dc.identifier.affiliationAlzheimer Centrum Vrije Universiteit Medical Center, VU University, Amsterdam, Netherlands.en
dc.identifier.doi10.1016/S1474-4422(14)70090-0en
dc.description.pages614-29en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/24849862en
dc.type.austinJournal Articleen
local.name.researcherRowe, Christopher C
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptMolecular Imaging and Therapy-
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