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Title: Systemic and renal haemodynamic effects of fluid bolus therapy: sodium chloride versus sodium octanoate-balanced solution.
Austin Authors: Ke, Lu;Calzavacca, Paolo;Bailey, Michael J;May, Clive N;Li, Wei-Qin;Bertolini, Joseph;Bellomo, Rinaldo 
Affiliation: Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
CSL Behring, Melbourne, Victoria, Australia
Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australia
Surgical Intensive Care Unit, Department of General Surgery, Jinling Hospital, Nanjing, China.
Issue Date: 1-Mar-2014
Publication information: Critical Care and Resuscitation; 16(1): 29-33
Abstract: Solutions with high chloride concentrations, like normal saline (NS), may adversely affect renal blood flow (RBF). We compared the systemic and renal haemodynamic effects of a bolus of NS with those of a novel isotonic solution containing a physiological concentration of chloride and sodium octanoate (SOct) in healthy conscious sheep.We performed an experimental double-blind cross-over animal study. After chronic pulmonary and renal artery flow probe insertion, animals were randomly assigned to receive rapid intravenous infusion (1 L over 30 minutes) of either NS or SOct. Haemodynamic parameters were recorded continuously before and after treatment.NS and SOct had similar dilutional effects on the haematocrit. Both induced a short-lived increase in cardiac output (CO) and total peripheral conductance which dissipated by 60 minutes. However, SOct increased RBF more than NS (peak values, 213.4±34.3mL/min v 179.3±35.6mL/min; P < 0.001) with a greater RBF/CO ratio (peak values, 12.2%±3.7% v 10.6%±3.6%; P < 0.001).NS and SOct appear to have similar systemic haemodynamic effects. However, OS significantly increases RBF compared with normal saline.
Gov't Doc #: 24588433
Journal: Critical Care and Resuscitation
Type: Journal Article
Subjects: Animals
Caprylates.administration & dosage
Critical Illness.therapy
Disease Models, Animal
Fluid Therapy.methods
Infusions, Intravenous
Regional Blood Flow.drug effects
Renal Circulation.drug effects
Sodium Chloride.administration & dosage
Appears in Collections:Journal articles

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