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dc.contributor.authorKe, Luen
dc.contributor.authorCalzavacca, Paoloen
dc.contributor.authorBailey, Michael Jen
dc.contributor.authorMay, Clive Nen
dc.contributor.authorLi, Wei-Qinen
dc.contributor.authorBertolini, Josephen
dc.contributor.authorBellomo, Rinaldoen
dc.identifier.citationCritical Care and Resuscitation; 16(1): 29-33en
dc.description.abstractSolutions with high chloride concentrations, like normal saline (NS), may adversely affect renal blood flow (RBF). We compared the systemic and renal haemodynamic effects of a bolus of NS with those of a novel isotonic solution containing a physiological concentration of chloride and sodium octanoate (SOct) in healthy conscious sheep.We performed an experimental double-blind cross-over animal study. After chronic pulmonary and renal artery flow probe insertion, animals were randomly assigned to receive rapid intravenous infusion (1 L over 30 minutes) of either NS or SOct. Haemodynamic parameters were recorded continuously before and after treatment.NS and SOct had similar dilutional effects on the haematocrit. Both induced a short-lived increase in cardiac output (CO) and total peripheral conductance which dissipated by 60 minutes. However, SOct increased RBF more than NS (peak values, 213.4±34.3mL/min v 179.3±35.6mL/min; P < 0.001) with a greater RBF/CO ratio (peak values, 12.2%±3.7% v 10.6%±3.6%; P < 0.001).NS and SOct appear to have similar systemic haemodynamic effects. However, OS significantly increases RBF compared with normal saline.en
dc.subject.otherCaprylates.administration & dosageen
dc.subject.otherCritical Illness.therapyen
dc.subject.otherDisease Models, Animalen
dc.subject.otherFluid Therapy.methodsen
dc.subject.otherInfusions, Intravenousen
dc.subject.otherRegional Blood Flow.drug effectsen
dc.subject.otherRenal Circulation.drug effectsen
dc.subject.otherSodium Chloride.administration & dosageen
dc.titleSystemic and renal haemodynamic effects of fluid bolus therapy: sodium chloride versus sodium octanoate-balanced solution.en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical Care and Resuscitationen
dc.identifier.affiliationDepartment of Intensive Care, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.affiliationFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australiaen
dc.identifier.affiliationCSL Behring, Melbourne, Victoria, Australiaen
dc.identifier.affiliationAustralian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, Victoria, Australiaen
dc.identifier.affiliationSurgical Intensive Care Unit, Department of General Surgery, Jinling Hospital, Nanjing, China.en
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications- Care- Analytics Research and Evaluation (DARE) Centre-
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