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Title: Diffusion-weighted MRI, 11C-choline PET and 18F-fluorodeoxyglucose PET for predicting the Gleason score in prostate carcinoma.
Austin Authors: Chang, Joe H;Lim Joon, Daryl ;Lee, Sze Ting ;Hiew, Chee-Yan;Esler, Stephen;Gong, Sylvia J;Wada, Morikatsu ;Clouston, David;O'Sullivan, Richard;Goh, Yin P;Tochon-Danguy, Henri;Chan, J Gordon ;Bolton, Damien M ;Scott, Andrew M ;Khoo, Vincent;Davis, Ian D
Affiliation: Radiation Oncology Centre, Austin Health, 300 Waterdale Road, Heidelberg, VIC, 3084, Australia,
Issue Date: 6-Nov-2013
Publication information: European Radiology 2013; 24(3): 715-22
Abstract: To evaluate the accuracy of transrectal ultrasound-guided (TRUS) biopsy, diffusion-weighted (DW) magnetic resonance imaging (MRI), (11)C-choline (CHOL) positron emission tomography (PET), and (18)F-fluorodeoxyglucose (FDG) PET in predicting the prostatectomy Gleason risk (GR).The study included 21 patients who underwent TRUS biopsy and multi-technique imaging before radical prostatectomy. Values from five different tests (TRUS biopsy, DW MRI, CHOL PET, FDG PET, and combined DW MRI/CHOL PET) were correlated with the prostatectomy GR using Spearman's ρ. Tests that were found to have significant correlations were used to classify patients into GR groups.The following tests had significant correlations with prostatectomy GR: TRUS biopsy (ρ = 0.617, P = 0.003), DW MRI (ρ = -0.601, P = 0.004), and combined DW MRI/CHOL PET (ρ = -0.623, P = 0.003). CHOL PET alone and FDG PET only had weak correlations. The correct GR classification rates were 67% with TRUS biopsy, 67% with DW MRI, and 76% with combined DW MRI/CHOL PET.DW MRI and combined DW MRI/CHOL PET have significant correlations and high rates of correct classification of the prostatectomy GR, the strength and accuracy of which are comparable with TRUS biopsy.• Accurate determination of the Gleason score is essential for prostate cancer management. • DW MRI ± CHOL PET correlated significantly with prostatectomy Gleason score. • These correlations are similar to that between TRUS biopsy and prostatectomy.
Gov't Doc #: 24192979
DOI: 10.1007/s00330-013-3045-1
Type: Journal Article
Subjects: Adenocarcinoma.diagnosis.pathology.radionuclide
Carbon Radioisotopes.diagnostic use
Choline.diagnostic use
Diffusion Magnetic Resonance Imaging.standards
Fluorodeoxyglucose F18.diagnostic use
Middle Aged
Neoplasm Grading
Positron-Emission Tomography.standards
Predictive Value of Tests
Prospective Studies
Prostatic Neoplasms.diagnosis.pathology.radionuclide
Radiopharmaceuticals.diagnostic use
Reproducibility of Results
Sensitivity and Specificity
Ultrasonography, Interventional
Appears in Collections:Journal articles

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