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Title: Deliberate fingolimod overdose presenting with delayed hypotension and bradycardia responsive to atropine.
Austin Authors: Stephenson, M;Wong, Anselm Y ;Rotella, Joe-Anthony ;Crump, Nicholas H ;Kerr, F;Greene, Shaun L 
Affiliation: Department of Emergency Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Jun-2014
Publication information: Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology; 10(2): 215-8
Abstract: Fingolimod is an immunomodulating agent used in multiple sclerosis (MS). It is a sphingosine-1-phosphate (S1P) receptor agonist prescribed for relapsing forms of MS to delay onset of physical disability. As fingolimod is known to cause first-dose bradycardia, telemetry is recommended for the first 6 h post-dose. We present the first reported case of deliberate fingolimod overdose requiring atropine administration for bradycardia and hemodynamic instability.A 33-year-old woman ingested 14 mg of fingolimod and 2 g of phenoxymethylpenicillin. After presenting to the emergency department 19 h later, she was initially hemodynamically stable (heart rate (HR) 60, blood pressure (BP) 113/89 mmHg). Two hours later, she then developed bradycardia (HR 48) and hypotension (87/57 mmHg). Despite intravenous fluids, stabilisation was only achieved after administration of atropine (300 μg). She was then admitted to the intensive care unit (ICU) for further monitoring where another episode of bradycardia and hypotension required atropine. She was monitored in the ICU for 48 h and then discharged on day 5 with no further episodes.Fingolimod is known to cause bradycardia in the first 6 h post first therapeutic dose. Following intentional overdose, onset of bradycardia occurred at 21 h post-ingestion and was associated with hypotension. Atropine was successful in treating bradycardia and associated hypotension.
DOI: 10.1007/s13181-013-0354-3
Type: Journal Article
Subjects: Adult
Antidotes.therapeutic use
Atropine.therapeutic use
Bradycardia.drug therapy.etiology
Combined Modality Therapy.adverse effects
Drug Overdose.physiopathology.therapy
Hypotension.drug therapy.etiology
Immunosuppressive Agents.antagonists & inhibitors.poisoning
Muscarinic Antagonists.therapeutic use
Propylene Glycols.antagonists & inhibitors.poisoning
Sphingosine.analogs & derivatives.antagonists & inhibitors.poisoning
Time Factors
Treatment Outcome
Appears in Collections:Journal articles

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