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Title: Androgens and prostate cancer; pathogenesis and deprivation therapy.
Austin Authors: Grossmann, Mathis ;Cheung, Ada S ;Zajac, Jeffrey D 
Affiliation: Dept. of Endocrinology, Austin Health, Victoria, Australia
Dept. of Medicine, Austin Health, University of Melbourne, Victoria, Australia
Issue Date: 5-Jun-2013
Publication information: Best Practice & Research. Clinical Endocrinology & Metabolism 2013; 27(4): 603-16
Abstract: Although androgen receptor signaling is critical for prostate cancer growth and survival, evidence supporting a favorable risk-benefit ratio of androgen deprivation therapy (ADT) is currently limited to men with high-risk or metastatic disease. This is in part because ADT has been associated with a number of constitutional and somatic side effects, consistent with the widespread tissue expression of sex steroid receptors. ADT is the most common contemporary cause of severe hypogonadism, and men receiving this therapy represent a unique model of severe sex steroid deficiency with a defined time of onset. This review will present an update on the role of ADT in the treatment of prostate cancer, will summarize recent evidence regarding ADT-associated adverse effects with particular emphasis on cardiometabolic and musculoskeletal health, and will provide recommendations for further research.
Gov't Doc #: 24054933
DOI: 10.1016/j.beem.2013.05.001
Type: Journal Article
Subjects: androgen deprivation therapy
insulin resistance
prostate cancer
Androgen Antagonists.adverse effects.therapeutic use
Androgens.therapeutic use
Bone Resorption.chemically induced
Diphosphonates.therapeutic use
Hypogonadism.chemically induced.physiopathology
Prostatic Neoplasms.drug therapy.epidemiology
Receptors, Androgen.drug effects
Appears in Collections:Journal articles

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