Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11834
Title: Normothermic extracorporeal human liver perfusion following donation after cardiac death.
Austin Authors: Bellomo, Rinaldo ;Marino, Bruno;Starkey, Graham;Wang, Bhao Zhong;Fink, Michael A ;Zhu, Nan;Suzuki, Satoshi;Houston, Shane;Eastwood, Glenn M ;Calzavacca, Paolo;Glassford, Neil J;Chambers, Brenton;Skene, Alison ;Schneider, Antoine G;Jones, Daryl A ;Hilton, Andrew;Opdam, Helen Ingrid;Warrillow, Stephen J ;Gauthier, Nicole;Johnson, Lynne;Jones, Robert M 
Affiliation: Department of Intensive Care, Austin Hospital, Melbourne, Victoria, Australia
Issue Date: 1-Jun-2013
Publication information: Critical Care and Resuscitation; 15(2): 78-82
Abstract: Liver transplantation is a major life-saving procedure and donation after cardiac death (DCD) has increased the pool of potential liver donors. However, livers procured after DCD are at increased risk of primary graft dysfunction and biliary tract ischaemia. Normothermic extracorporeal liver perfusion (NELP) may increase the ability to protect, evaluate and, in future, transplant DCD livers. We conducted a proof-of-concept experiment using a human liver procured by DCD (deemed not suitable for liver donation) to assess the short-term (3 hours) feasibility, histological effects and functional efficacy of NELP. We used an extracorporeal membrane oxygenation circuit with separate hepatic artery and portal vein perfusion to achieve physiological perfusion pressures, and coupled this with parenteral nutrition and an insulin infusion. We achieved NELP with evidence of liver function (bile production, paracetamol removal and control of ammonia, bilirubin and lactate levels) for 3 hours. There was essentially normal liver and biliary tract histology after 8 hours of perfusion. Our experiment justifies further investigation of the feasibility and efficacy of human DCD liver preservation by NELP.
Gov't Doc #: 23931037
URI: http://ahro.austin.org.au/austinjspui/handle/1/11834
URL: https://pubmed.ncbi.nlm.nih.gov/23931037
Type: Journal Article
Subjects: Aged
Death
Extracorporeal Circulation.methods
Humans
Liver Failure.surgery
Liver Transplantation.methods
Male
Organ Preservation.methods
Perfusion.methods
Tissue Donors
Appears in Collections:Journal articles

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