Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11834
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBellomo, Rinaldo-
dc.contributor.authorMarino, Bruno-
dc.contributor.authorStarkey, Graham-
dc.contributor.authorWang, Bhao Zhong-
dc.contributor.authorFink, Michael A-
dc.contributor.authorZhu, Nan-
dc.contributor.authorSuzuki, Satoshi-
dc.contributor.authorHouston, Shane-
dc.contributor.authorEastwood, Glenn M-
dc.contributor.authorCalzavacca, Paolo-
dc.contributor.authorGlassford, Neil J-
dc.contributor.authorChambers, Brenton-
dc.contributor.authorSkene, Alison-
dc.contributor.authorSchneider, Antoine G-
dc.contributor.authorJones, Daryl A-
dc.contributor.authorHilton, Andrew-
dc.contributor.authorOpdam, Helen Ingrid-
dc.contributor.authorWarrillow, Stephen J-
dc.contributor.authorGauthier, Nicole-
dc.contributor.authorJohnson, Lynne-
dc.contributor.authorJones, Robert M-
dc.date.accessioned2015-05-16T01:27:47Z-
dc.date.available2015-05-16T01:27:47Z-
dc.date.issued2013-06-01-
dc.identifier.citationCritical Care and Resuscitation; 15(2): 78-82en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11834en
dc.description.abstractLiver transplantation is a major life-saving procedure and donation after cardiac death (DCD) has increased the pool of potential liver donors. However, livers procured after DCD are at increased risk of primary graft dysfunction and biliary tract ischaemia. Normothermic extracorporeal liver perfusion (NELP) may increase the ability to protect, evaluate and, in future, transplant DCD livers. We conducted a proof-of-concept experiment using a human liver procured by DCD (deemed not suitable for liver donation) to assess the short-term (3 hours) feasibility, histological effects and functional efficacy of NELP. We used an extracorporeal membrane oxygenation circuit with separate hepatic artery and portal vein perfusion to achieve physiological perfusion pressures, and coupled this with parenteral nutrition and an insulin infusion. We achieved NELP with evidence of liver function (bile production, paracetamol removal and control of ammonia, bilirubin and lactate levels) for 3 hours. There was essentially normal liver and biliary tract histology after 8 hours of perfusion. Our experiment justifies further investigation of the feasibility and efficacy of human DCD liver preservation by NELP.en_US
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherDeathen
dc.subject.otherExtracorporeal Circulation.methodsen
dc.subject.otherHumansen
dc.subject.otherLiver Failure.surgeryen
dc.subject.otherLiver Transplantation.methodsen
dc.subject.otherMaleen
dc.subject.otherOrgan Preservation.methodsen
dc.subject.otherPerfusion.methodsen
dc.subject.otherTissue Donorsen
dc.titleNormothermic extracorporeal human liver perfusion following donation after cardiac death.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleCritical Care and Resuscitationen_US
dc.identifier.affiliationIntensive Careen_US
dc.description.pages78-82en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/23931037en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherBellomo, Rinaldo
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptSurgery-
crisitem.author.deptIntensive Care-
crisitem.author.deptPathology-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptSurgery (University of Melbourne)-
crisitem.author.deptHepatopancreatobiliary Surgery-
crisitem.author.deptGastroenterology and Hepatology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

26
checked on Mar 28, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.