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|Title:||Toll-like receptors in hepatitis C infection: implications for pathogenesis and treatment.||Austin Authors:||Howell, Jessica;Angus, Peter W ;Gow, Paul J ;Visvanathan, Kumar||Affiliation:||Liver Transplant Unit, Austin Hospital, Victoria, Australia||Issue Date:||1-May-2013||Publication information:||Journal of Gastroenterology and Hepatology; 28(5): 766-76||Abstract:||Hepatitis C virus (HCV) infection is a significant global health problem, affecting over 150 million people worldwide. While the critical role of the adaptive immune system in HCV infection is well-established, the importance of the innate immune system in HCV infection has only been recognized in more recent years. Toll-like receptors form the cornerstone of the innate immune response, and there is considerable evidence for their crucial role in hepatitis C infection. This review outlines recent advances made in our understanding of the role of Toll-like receptor function in HCV infection, exploring how HCV manipulates host immunity to evade immune clearance and establish persistent infection despite leading to inflammatory hepatic damage.||Gov't Doc #:||23432473||URI:||http://ahro.austin.org.au/austinjspui/handle/1/11681||DOI:||10.1111/jgh.12170||Journal:||Journal of Gastroenterology and Hepatology||URL:||https://pubmed.ncbi.nlm.nih.gov/23432473||Type:||Journal Article||Subjects:||Adaptive Immunity.immunology
Molecular Targeted Therapy
|Appears in Collections:||Journal articles|
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