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Title: Bubble chamber clotting during continuous renal replacement therapy: vertical versus horizontal blood flow entry.
Austin Authors: Baldwin, Ian C ;Fealy, Nigel G ;Carty, Paula ;Boyle, Martin;Kim, In Byung;Bellomo, Rinaldo 
Affiliation: Department of Intensive Care, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 18-Oct-2012
Publication information: Blood Purification 2012; 34(3-4): 213-8
Abstract: The continuous renal replacement therapy (CRRT) bubble trap chamber is a frequent site of clotting.To assess clot formation when comparing our standard 'vertical' blood entry chamber (BEC) with a new 'horizontal' BEC.Adult ICU patients requiring CRRT were treated with the vertical BEC and then a similar subsequent cohort with the horizontal BEC in continuous veno-venous haemofiltration mode.40 chambers were assessed for each design. Circuit life was 13.9 ± 9.5 h for the vertical and 17.7 ± 15.9 h for the horizontal BEC (p = 0.33). APTT, however, was higher for the horizontal BEC (55.7 ± 34.7 vs. 37.4 ± 9.0, p < 0.002) and no difference in circuit life was found after multivariable analysis. A clotting score ≥3 was observed in 85% of all chambers. There was no difference in chamber clotting score (vertical 3.6 ± 1.03 vs. horizontal 3.8 ± 1.0, p = 0.5). In addition, no difference was found when scores were divided into two groups using a 'likelihood' to clot analysis (p = 1.0).CRRT horizontal BEC were not associated with less clotting compared to our standard vertical BEC.
Gov't Doc #: 23095781
DOI: 10.1159/000342596
Journal: Blood Purification
Type: Journal Article
Subjects: Blood Coagulation
Hemofiltration.adverse effects.methods
Hospital Mortality
Intensive Care Units
Prospective Studies
Renal Replacement Therapy.adverse effects.instrumentation.methods
Appears in Collections:Journal articles

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