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Title: Relationship between vancomycin-resistant Staphylococcus aureus, vancomycin-intermediate S. aureus, high vancomycin MIC, and outcome in serious S. aureus infections.
Austin Authors: Holmes, Natasha E ;Johnson, Paul D R ;Howden, Benjamin P 
Affiliation: Austin Centre for Infection Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, USA
Issue Date: 16-May-2012
Publication information: Journal of Clinical Microbiology 2012; 50(8): 2548-52
Abstract: Vancomycin has been used successfully for over 50 years for the treatment of Staphylococcus aureus infections, particularly those involving methicillin-resistant S. aureus. It has proven remarkably reliable, but its efficacy is now being questioned with the emergence of strains of S. aureus that display heteroresistance, intermediate resistance, and, occasionally, complete vancomycin resistance. More recently, an association has been established between poor outcome and infections with strains of S. aureus with an elevated vancomycin MIC within the susceptible range. This minireview summarizes the definitions, mechanisms, clinical impact, and laboratory identification of reduced vancomycin susceptibility in S. aureus and discusses practical issues for the diagnostic laboratory in testing and interpreting vancomycin susceptibility for S. aureus infections.
Gov't Doc #: 22593595
DOI: 10.1128/JCM.00775-12
Type: Journal Article
Subjects: Anti-Bacterial Agents.therapeutic use
Microbial Sensitivity Tests
Staphylococcal Infections.diagnosis.drug therapy.microbiology
Staphylococcus aureus.drug effects
Treatment Outcome
Vancomycin Resistance
Appears in Collections:Journal articles

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