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|Title:||The frontal lobe in absence epilepsy: EEG-fMRI findings.||Austin Authors:||Carney, Patrick W ;Masterton, Richard A J;Flanagan, D;Berkovic, Samuel F ;Jackson, Graeme D||Affiliation:||Austin Health, Brain Research Institute, Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australia
|Issue Date:||28-Mar-2012||Publication information:||Neurology 2012; 78(15): 1157-65||Abstract:||Studies of absence seizures (AS) using EEG with fMRI (EEG-fMRI) show a consistent network with prominent thalamic activation and a variety of cortical changes. Despite evidence suggesting a role of frontal cortex in seizure generation, group studies have not detected consistent AS-related changes in this region. We hypothesized that only a subgroup may show frontal cortical activation.We studied 13 subjects with AS during EEG-fMRI to classify the different individual patterns of frontal cortical activation associated with AS.Based upon visual inspection of surface-rendered activation maps we identified 2 subgroups that could be distinguished by the activation in the dorsolateral prefrontal cortex (DLPFC). One group of patients (n = 7) showed a primarily positive signal change (DLPFC-POS), whereas the other group (n = 6) showed a primarily negative signal change (DLFPC-NEG). When the DLPFC-POS group was compared to the DLPFC-NEG group, time-course analysis revealed a larger positive blood oxygenation level-dependent deflection following onset of the AS in cortical and subcortical areas beyond the DLPFC. This suggests a basic biological difference between these groups.These observations suggest that there may be at least 2 mechanisms underpinning AS in individuals with absence epilepsy. This may have phenotypic and genetic implications for understanding epilepsy syndromes.||URI:||https://ahro.austin.org.au/austinjspui/handle/1/11467||DOI:||10.1212/WNL.0b013e31824f801d||ORCID:||Journal:||Neurology||URL:||https://pubmed.ncbi.nlm.nih.gov/22459682||Type:||Journal Article||Subjects:||Adolescent
Magnetic Resonance Imaging
|Appears in Collections:||Journal articles|
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