Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11467
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dc.contributor.authorCarney, Patrick W-
dc.contributor.authorMasterton, Richard A J-
dc.contributor.authorFlanagan, D-
dc.contributor.authorBerkovic, Samuel F-
dc.contributor.authorJackson, Graeme D-
dc.date.accessioned2015-05-16T01:04:43Z
dc.date.available2015-05-16T01:04:43Z
dc.date.issued2012-03-28-
dc.identifier.citationNeurology 2012; 78(15): 1157-65en_US
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11467en
dc.description.abstractStudies of absence seizures (AS) using EEG with fMRI (EEG-fMRI) show a consistent network with prominent thalamic activation and a variety of cortical changes. Despite evidence suggesting a role of frontal cortex in seizure generation, group studies have not detected consistent AS-related changes in this region. We hypothesized that only a subgroup may show frontal cortical activation.We studied 13 subjects with AS during EEG-fMRI to classify the different individual patterns of frontal cortical activation associated with AS.Based upon visual inspection of surface-rendered activation maps we identified 2 subgroups that could be distinguished by the activation in the dorsolateral prefrontal cortex (DLPFC). One group of patients (n = 7) showed a primarily positive signal change (DLPFC-POS), whereas the other group (n = 6) showed a primarily negative signal change (DLFPC-NEG). When the DLPFC-POS group was compared to the DLPFC-NEG group, time-course analysis revealed a larger positive blood oxygenation level-dependent deflection following onset of the AS in cortical and subcortical areas beyond the DLPFC. This suggests a basic biological difference between these groups.These observations suggest that there may be at least 2 mechanisms underpinning AS in individuals with absence epilepsy. This may have phenotypic and genetic implications for understanding epilepsy syndromes.en_US
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherChilden
dc.subject.otherChild, Preschoolen
dc.subject.otherElectroencephalographyen
dc.subject.otherEpilepsy, Absence.pathology.physiopathologyen
dc.subject.otherFemaleen
dc.subject.otherFrontal Lobe.pathology.physiopathologyen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imagingen
dc.subject.otherMaleen
dc.subject.otherPrefrontal Cortex.physiopathologyen
dc.titleThe frontal lobe in absence epilepsy: EEG-fMRI findings.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleNeurologyen_US
dc.identifier.affiliationAustin Health, Brain Research Institute, Department of Medicine, University of Melbourne, Heidelberg, Victoria, Australiaen_US
dc.identifier.affiliationAustin Healthen_US
dc.identifier.doi10.1212/WNL.0b013e31824f801den_US
dc.description.pages1157-65en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/22459682en
dc.type.contentTexten_US
dc.type.austinJournal Articleen
local.name.researcherBerkovic, Samuel F
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
crisitem.author.deptNeurology-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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