Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11388
Title: Less fat reduction per unit weight loss in type 2 diabetic compared with nondiabetic obese individuals completing a very-low-calorie diet program.
Austin Authors: Baker, Scott T ;Jerums, George ;Prendergast, Luke A;Panagiotopoulos, Sianna ;Strauss, Boyd J;Proietto, Joseph 
Affiliation: Endocrine Centre, Austin Health, Heidelberg Repatriation Hospital Campus, Heidelberg West, Victoria, Australia
Issue Date: 5-Dec-2011
Publication information: Metabolism: Clinical and Experimental 2011; 61(6): 873-82
Abstract: The objective was to compare weight loss and change in body composition in obese subjects with and without type 2 diabetes mellitus during a very-low-calorie diet (VLCD) program. Seventy weight-matched subjects with diabetes or normal fasting glucose (controls) participated in a 24-week VLCD study. Primary end points were changes in anthropometry, body composition, and fasting plasma insulin and β-hydroxybutyrate concentrations. Fifty-one subjects (24 with diabetes) completed the study. No difference in weight loss between the 2 groups at 24 weeks was found by intention-to-treat analysis. Both groups completing the study per protocol had near-identical weight change during the program, with similar weight loss at 24 weeks (diabetes: 8.5 ± 1.3 kg vs control: 9.4 ± 1.2 kg, P = .64). Change in fat mass index correlated with change in body mass index (BMI) in both groups (diabetes: r = 0.878, control: r = 0.920, both P < .001); but change in fat mass index per unit change in BMI was less in the diabetic group compared with controls (0.574 vs 0.905 decrease, P = .003), which persisted after adjusting for age, sex, and baseline BMI (P = .008). Insulin concentrations remained higher and peak β-hydroxybutyrate concentrations were lower in the diabetic compared with the control group. While following a 24-week VLCD program, obese subjects with and without diabetes achieved comparable weight loss; but the decrease in adiposity per unit weight loss was attenuated in diabetic subjects. Hyperinsulinemia may have inhibited lipolysis in the diabetic group; however, further investigation into other factors is needed.
Gov't Doc #: 22146094
URI: http://ahro.austin.org.au/austinjspui/handle/1/11388
DOI: 10.1016/j.metabol.2011.10.017
ORCID: 0000-0002-0845-0001
URL: https://pubmed.ncbi.nlm.nih.gov/22146094
Type: Journal Article
Subjects: Adult
Aged
Body Composition.physiology
Caloric Restriction
Case-Control Studies
Diabetes Mellitus, Type 2.complications.diet therapy.physiopathology
Diet, Reducing
Female
Humans
Male
Middle Aged
Obesity.complications.diet therapy.physiopathology
Prospective Studies
Treatment Outcome
Weight Loss.physiology
Appears in Collections:Journal articles

Show full item record

Page view(s)

16
checked on Dec 5, 2022

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.