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Title: Improved normal tissue sparing in head and neck radiotherapy using biological cost function based-IMRT.
Austin Authors: Anderson, N;Lawford, C;Khoo, Vincent;Rolfo, M;Joon, D L;Wada, Morikatsu 
Affiliation: Department of Radiation Oncology, Austin Health, Heidelberg Heights, Victoria, Australia
Issue Date: 1-Dec-2011
Publication information: Technology in Cancer Research & Treatment; 10(6): 575-83
Abstract: Intensity-modulated radiotherapy (IMRT) has reduced the impact of acute and late toxicities associated with head and neck radiotherapy. Treatment planning system (TPS) advances in biological cost function based optimization (BBO) and improved segmentation techniques have increased organ at risk (OAR) sparing compared to conventional dose-based optimization (DBO). A planning study was undertaken to compare OAR avoidance in DBO and BBO treatment planning. Simultaneous integrated boost treatment plans were produced for 10 head and neck patients using both planning systems. Plans were compared for tar get coverage and OAR avoidance. Comparisons were made using the BBO TPS Monte Carlo dose engine to eliminate differences due to inherent algorithms. Target coverage (V95%) was maintained for both solutions. BBO produced lower OAR doses, with statistically significant improvement to left (12.3%, p = 0.005) and right parotid mean dose (16.9%, p = 0.004), larynx V50_Gy (71.0%, p = 0.005), spinal cord (21.9%, p < 0.001) and brain stem dose maximums (31.5%, p = 0.002). This study observed improved OAR avoidance with BBO planning. Further investigations will be undertaken to review any clinical benefit of this improved planned dosimetry.
Gov't Doc #: 22066597
Journal: Technology in cancer research & treatment
Type: Journal Article
Subjects: Carcinoma, Squamous Cell.radiotherapy
Head.radiation effects
Head and Neck Neoplasms.radiotherapy
Middle Aged
Monte Carlo Method
Neck.radiation effects
Neoplasm Staging
Organ Sparing Treatments
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Conformal
Radiotherapy, Intensity-Modulated
Relative Biological Effectiveness
Appears in Collections:Journal articles

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