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dc.contributor.authorAnderson, Nen
dc.contributor.authorLawford, Cen
dc.contributor.authorKhoo, Vincenten
dc.contributor.authorRolfo, Men
dc.contributor.authorJoon, D Len
dc.contributor.authorWada, Morikatsuen
dc.identifier.citationTechnology in Cancer Research & Treatment; 10(6): 575-83en
dc.description.abstractIntensity-modulated radiotherapy (IMRT) has reduced the impact of acute and late toxicities associated with head and neck radiotherapy. Treatment planning system (TPS) advances in biological cost function based optimization (BBO) and improved segmentation techniques have increased organ at risk (OAR) sparing compared to conventional dose-based optimization (DBO). A planning study was undertaken to compare OAR avoidance in DBO and BBO treatment planning. Simultaneous integrated boost treatment plans were produced for 10 head and neck patients using both planning systems. Plans were compared for tar get coverage and OAR avoidance. Comparisons were made using the BBO TPS Monte Carlo dose engine to eliminate differences due to inherent algorithms. Target coverage (V95%) was maintained for both solutions. BBO produced lower OAR doses, with statistically significant improvement to left (12.3%, p = 0.005) and right parotid mean dose (16.9%, p = 0.004), larynx V50_Gy (71.0%, p = 0.005), spinal cord (21.9%, p < 0.001) and brain stem dose maximums (31.5%, p = 0.002). This study observed improved OAR avoidance with BBO planning. Further investigations will be undertaken to review any clinical benefit of this improved planned dosimetry.en
dc.subject.otherCarcinoma, Squamous Cell.radiotherapyen
dc.subject.otherHead.radiation effectsen
dc.subject.otherHead and Neck Neoplasms.radiotherapyen
dc.subject.otherMiddle Ageden
dc.subject.otherMonte Carlo Methoden
dc.subject.otherNeck.radiation effectsen
dc.subject.otherNeoplasm Stagingen
dc.subject.otherOrgan Sparing Treatmentsen
dc.subject.otherRadiotherapy Planning, Computer-Assisteden
dc.subject.otherRadiotherapy, Conformalen
dc.subject.otherRadiotherapy, Intensity-Modulateden
dc.subject.otherRelative Biological Effectivenessen
dc.titleImproved normal tissue sparing in head and neck radiotherapy using biological cost function based-IMRT.en
dc.typeJournal Articleen
dc.identifier.journaltitleTechnology in cancer research & treatmenten
dc.identifier.affiliationDepartment of Radiation Oncology, Austin Health, Heidelberg Heights, Victoria, Australiaen
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications- Oncology- Newton-John Cancer Wellness and Research Centre-
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