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https://ahro.austin.org.au/austinjspui/handle/1/11352| Title: | Pharmacokinetic and pharmacodynamic effects of a single nocturnal dose of alprazolam. | Austin Authors: | Norman, Trevor R ;Burrows, Graham D;McIntyre, I M | Affiliation: | Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 1-Apr-1990 | Publication information: | International Clinical Psychopharmacology; 5(2): 111-7 | Abstract: | Six healthy volunteers participated in a study of the pharmacokinetic and psychomotor effects of a single dose of 2 mg of alprazolam compared to placebo when given at night. Alprazolam reached a maximum concentration in the plasma between 0.5 and 2.5 h after the dose. It was extensively distributed to the tissues as shown by the large apparent volume of distribution (1.42 l/kg) and slowly eliminated (t1/2 = 13.7 h). Significant impairment of choice reaction time occurred 1 and 11 h after the dose of alprazolam compared to placebo. Critical flicker fusion was also impaired after alprazolam but the difference from the placebo administration did not reach significance. | Gov't Doc #: | 2199575 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/11352 | Journal: | International clinical psychopharmacology | URL: | https://pubmed.ncbi.nlm.nih.gov/2199575 | Type: | Journal Article | Subjects: | Administration, Oral Adult Alprazolam.administration & dosage.pharmacokinetics Arousal.drug effects Double-Blind Method Drug Administration Schedule Female Flicker Fusion.drug effects Humans Male Randomized Controlled Trials as Topic Sensory Thresholds.drug effects |
| Appears in Collections: | Journal articles |
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