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Title: Pharmacokinetic and pharmacodynamic effects of a single nocturnal dose of alprazolam.
Austin Authors: Norman, Trevor R ;Burrows, Graham D;McIntyre, I M
Affiliation: Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Apr-1990
Publication information: International Clinical Psychopharmacology; 5(2): 111-7
Abstract: Six healthy volunteers participated in a study of the pharmacokinetic and psychomotor effects of a single dose of 2 mg of alprazolam compared to placebo when given at night. Alprazolam reached a maximum concentration in the plasma between 0.5 and 2.5 h after the dose. It was extensively distributed to the tissues as shown by the large apparent volume of distribution (1.42 l/kg) and slowly eliminated (t1/2 = 13.7 h). Significant impairment of choice reaction time occurred 1 and 11 h after the dose of alprazolam compared to placebo. Critical flicker fusion was also impaired after alprazolam but the difference from the placebo administration did not reach significance.
Gov't Doc #: 2199575
Type: Journal Article
Subjects: Administration, Oral
Alprazolam.administration & dosage.pharmacokinetics
Arousal.drug effects
Double-Blind Method
Drug Administration Schedule
Flicker Fusion.drug effects
Randomized Controlled Trials as Topic
Sensory Thresholds.drug effects
Appears in Collections:Journal articles

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