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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11352
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dc.contributor.authorNorman, Trevor Ren
dc.contributor.authorBurrows, Graham Den
dc.contributor.authorMcIntyre, I Men
dc.date.accessioned2015-05-16T00:56:32Z
dc.date.available2015-05-16T00:56:32Z
dc.date.issued1990-04-01en
dc.identifier.citationInternational Clinical Psychopharmacology; 5(2): 111-7en
dc.identifier.govdoc2199575en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11352en
dc.description.abstractSix healthy volunteers participated in a study of the pharmacokinetic and psychomotor effects of a single dose of 2 mg of alprazolam compared to placebo when given at night. Alprazolam reached a maximum concentration in the plasma between 0.5 and 2.5 h after the dose. It was extensively distributed to the tissues as shown by the large apparent volume of distribution (1.42 l/kg) and slowly eliminated (t1/2 = 13.7 h). Significant impairment of choice reaction time occurred 1 and 11 h after the dose of alprazolam compared to placebo. Critical flicker fusion was also impaired after alprazolam but the difference from the placebo administration did not reach significance.en
dc.language.isoenen
dc.subject.otherAdministration, Oralen
dc.subject.otherAdulten
dc.subject.otherAlprazolam.administration & dosage.pharmacokineticsen
dc.subject.otherArousal.drug effectsen
dc.subject.otherDouble-Blind Methoden
dc.subject.otherDrug Administration Scheduleen
dc.subject.otherFemaleen
dc.subject.otherFlicker Fusion.drug effectsen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherRandomized Controlled Trials as Topicen
dc.subject.otherSensory Thresholds.drug effectsen
dc.titlePharmacokinetic and pharmacodynamic effects of a single nocturnal dose of alprazolam.en
dc.typeJournal Articleen
dc.identifier.journaltitleInternational clinical psychopharmacologyen
dc.identifier.affiliationDepartment of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages111-7en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/2199575en
dc.type.austinJournal Articleen
local.name.researcherNorman, Trevor R
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptPsychiatry (University of Melbourne)-
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