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Title: Association of ACE2 genetic variants with blood pressure, left ventricular mass, and cardiac function in Caucasians with type 2 diabetes.
Austin Authors: Patel, Sheila K ;Wai, Bryan;Ord, Michelle;MacIsaac, Richard J;Grant, Sharon L;Velkoska, Elena;Panagiotopoulos, Sianna ;Jerums, George ;Srivastava, Piyush M ;Burrell, Louise M 
Affiliation: Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 13-Oct-2011
Publication information: American Journal of Hypertension 2011; 25(2): 216-22
Abstract: Cardiovascular disease is common in diabetes, and is associated with activation of the renin-angiotensin system (RAS). Angiotensin-converting enzyme (ACE)2 is a recently described member of the RAS, and this study investigated whether ACE2 polymorphisms are associated with hypertension, left ventricular (LV) mass, and cardiac function in type 2 diabetes.Variants in ACE2 (rs1978124, rs2074192, rs4240157, rs4646156, rs4646188) were examined in 503 Caucasian subjects with type 2 diabetes. As ACE2 is located on the X chromosome, analyses were performed separately for men and women. Hypertension was defined by a history of hypertension, and/or antihypertensive medications or blood pressure (BP) >130/80 mm Hg. LV mass and systolic function (ejection fraction) were assessed by transthoracic echocardiography.In men, hypertension was more prevalent with the ACE2 rs2074192 C allele (P = 0.023), rs4240157 G allele (P = 0.016) and rs4646188 T allele (P = 0.006). In men, the rs1978124 A allele was associated with a significantly lower ejection fraction compared to the G allele (62.3 ± 13.3 vs. 67.2 ± 10.9%, P = 0.002). This association remained significant after covariate adjustment for age, body mass index, hypertension, antihypertensive treatment, and BP. In women, the prevalence of hypertension was higher (P = 0.009) with the rs4240157 G allele, and the rs1978124 A allele was associated with significantly higher LV mass (P = 0.008).In Caucasians with type 2 diabetes, genetic variation in ACE2 is associated with hypertension and reduced systolic function in men, and hypertension and increased LV mass in women.
Gov't Doc #: 21993363
DOI: 10.1038/ajh.2011.188
ORCID: 0000-0002-0845-0001
Type: Journal Article
Subjects: Adult
Blood Pressure.genetics
Diabetes Mellitus, Type 2.complications.epidemiology.physiopathology
European Continental Ancestry Group.genetics.statistics & numerical data
Genetic Association Studies
Genetic Variation
Hypertrophy, Left Ventricular.genetics.physiopathology.ultrasonography
Middle Aged
Peptidyl-Dipeptidase A.genetics
Stroke Volume.genetics
Appears in Collections:Journal articles

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