Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11350
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPatel, Sheila Ken
dc.contributor.authorWai, Bryanen
dc.contributor.authorOrd, Michelleen
dc.contributor.authorMacIsaac, Richard Jen
dc.contributor.authorGrant, Sharon Len
dc.contributor.authorVelkoska, Elenaen
dc.contributor.authorPanagiotopoulos, Siannaen
dc.contributor.authorJerums, Georgeen
dc.contributor.authorSrivastava, Piyush Men
dc.contributor.authorBurrell, Louise Men
dc.date.accessioned2015-05-16T00:56:25Z-
dc.date.available2015-05-16T00:56:25Z-
dc.date.issued2011-10-13en
dc.identifier.citationAmerican Journal of Hypertension 2011; 25(2): 216-22en
dc.identifier.govdoc21993363en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11350en
dc.description.abstractCardiovascular disease is common in diabetes, and is associated with activation of the renin-angiotensin system (RAS). Angiotensin-converting enzyme (ACE)2 is a recently described member of the RAS, and this study investigated whether ACE2 polymorphisms are associated with hypertension, left ventricular (LV) mass, and cardiac function in type 2 diabetes.Variants in ACE2 (rs1978124, rs2074192, rs4240157, rs4646156, rs4646188) were examined in 503 Caucasian subjects with type 2 diabetes. As ACE2 is located on the X chromosome, analyses were performed separately for men and women. Hypertension was defined by a history of hypertension, and/or antihypertensive medications or blood pressure (BP) >130/80 mm Hg. LV mass and systolic function (ejection fraction) were assessed by transthoracic echocardiography.In men, hypertension was more prevalent with the ACE2 rs2074192 C allele (P = 0.023), rs4240157 G allele (P = 0.016) and rs4646188 T allele (P = 0.006). In men, the rs1978124 A allele was associated with a significantly lower ejection fraction compared to the G allele (62.3 ± 13.3 vs. 67.2 ± 10.9%, P = 0.002). This association remained significant after covariate adjustment for age, body mass index, hypertension, antihypertensive treatment, and BP. In women, the prevalence of hypertension was higher (P = 0.009) with the rs4240157 G allele, and the rs1978124 A allele was associated with significantly higher LV mass (P = 0.008).In Caucasians with type 2 diabetes, genetic variation in ACE2 is associated with hypertension and reduced systolic function in men, and hypertension and increased LV mass in women.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAgeden
dc.subject.otherBlood Pressure.geneticsen
dc.subject.otherDiabetes Mellitus, Type 2.complications.epidemiology.physiopathologyen
dc.subject.otherEuropean Continental Ancestry Group.genetics.statistics & numerical dataen
dc.subject.otherFemaleen
dc.subject.otherGenetic Association Studiesen
dc.subject.otherGenetic Variationen
dc.subject.otherHeart.physiopathologyen
dc.subject.otherHumansen
dc.subject.otherHypertension.epidemiology.genetics.physiopathology.ultrasonographyen
dc.subject.otherHypertrophy, Left Ventricular.genetics.physiopathology.ultrasonographyen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherPeptidyl-Dipeptidase A.geneticsen
dc.subject.otherPrevalenceen
dc.subject.otherStroke Volume.geneticsen
dc.titleAssociation of ACE2 genetic variants with blood pressure, left ventricular mass, and cardiac function in Caucasians with type 2 diabetes.en
dc.typeJournal Articleen
dc.identifier.journaltitleAmerican Journal of Hypertensionen
dc.identifier.affiliationDepartment of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia en
dc.identifier.doi10.1038/ajh.2011.188en
dc.description.pages216-22en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/21993363en
dc.identifier.orcid0000-0002-0845-0001-
dc.identifier.orcid0000-0003-1863-7539-
dc.type.austinJournal Articleen
local.name.researcherBurrell, Louise M
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptOffice for Research-
crisitem.author.deptEndocrinology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCardiology-
crisitem.author.deptGeneral Medicine-
crisitem.author.deptMedicine (University of Melbourne)-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

38
checked on Mar 27, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.