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Title: New approaches for the evaluation of renal vascular function in diabetes.
Austin Authors: Jerums, George ;MacIsaac, Richard J
Affiliation: Endocrine Centre, Austin Health & University of Melbourne, Heidelberg Repatriation Hospital, Heidelberg West, PO Box 5444, VIC 3081, Australia
Issue Date: 28-Jun-2011
Publication information: Diabetologia 2011; 54(9): 2223-5
Abstract: In this issue of Diabetologia, two new approaches are described for the assessment of intra-renal blood flow in people with diabetes. The first approach used the technique of dynamic assessment of the resistance index (RI) in the renal interlobar arteries before and after administration of sublingual glyceryl trinitrate, and the second used MRI to assess total renal blood flow in relation to mean arterial pressure, thereby enabling direct measurement of overall renal RI. The results of the first study raise the possibility that dynamic evaluation of the intra-renal RI could be used as an early detector of vascular alterations in type 2 diabetes, before the onset of microalbuminuria. The results of the second study suggest that decreases in renal blood flow in people with longstanding type 1 diabetes reflect intra-renal vascular stiffening and raise the possibility that in microalbuminuric patients it may also reflect increased intraglomerular pressure.
Gov't Doc #: 21710288
DOI: 10.1007/s00125-011-2225-2
Type: Journal Article
Subjects: Albuminuria.physiopathology
Diabetes Mellitus, Type 1.complications.pathology
Diabetes Mellitus, Type 2.physiopathology
Diabetic Nephropathies.etiology.pathology
Kidney.blood supply
Magnetic Resonance Imaging.methods
Regional Blood Flow.physiology
Appears in Collections:Journal articles

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