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Title: Impaired arterial baroreceptor reflex and cardiopulmonary vagal reflex in conscious spontaneously hypertensive rats.
Austin Authors: Widdop, Robert E;Verberne, Anthony J M ;Jarrott, B;Louis, William J 
Affiliation: University of Melbourne, Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Mar-1990
Publication information: Journal of Hypertension; 8(3): 269-75
Abstract: The activity of baroreceptor reflexes and cardiopulmonary reflexes was examined in conscious spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) rats. The baroreceptor heart rate reflex, elicited by phenylephrine- and nitroprusside-induced changes in blood pressure, had a reduced range and lower heart rate plateau in SHR than in WKY rats, which suggests impaired vagal control of the heart rate in SHR. Cardiopulmonary receptor reflex activity was assessed by intravenous injections of phenyldiguanide which evoke the Bezold-Jarisch reflex. Phenyldiguanide elicited dose-dependent bradycardic and hypotensive responses in WKY rats, but these were significantly attenuated in SHR. This is the first demonstration of impaired Bezold-Jarisch responses in conscious SHR and provides evidence of both impaired vagally mediated arterial baroreceptor activity and impaired cardiopulmonary receptor activity in this rat strain.
Gov't Doc #: 2159508
Type: Journal Article
Subjects: Animals
Biguanides.administration & dosage.pharmacology
Blood Pressure.drug effects
Dose-Response Relationship, Drug
Heart Rate.drug effects
Pressoreceptors.drug effects.physiopathology
Rats, Inbred SHR
Rats, Inbred WKY
Reflex, Abnormal.drug effects
Vagus Nerve.physiopathology
Appears in Collections:Journal articles

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