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Title: Cerebral β-amyloid detected by Pittsburgh compound B positron emission topography predisposes to recombinant tissue plasminogen activator-related hemorrhage.
Austin Authors: Ly, John V;Rowe, Christopher C ;Villemagne, Victor L ;Zavala, Jorge A;Ma, Henry K;O'Keefe, Graeme J;Gong, Sylvia J;Gunawan, Rico;Churilov, Leonid ;Saunder, Tim;Ackerman, Uwe;Tochon-Danguy, Henri;Donnan, Geoffrey A 
Affiliation: National Stroke Research Institute, Austin Health, University of Melbourne, Heidelberg Heights, Australia
Issue Date: 1-Dec-2010
Publication information: Annals of Neurology; 68(6): 959-62
Abstract: Cerebral amyloid angiopathy (CAA) may be an important predisposing factor for the hemorrhagic complications of recombinant tissue-type plasminogen activator (rt-PA) therapy. We studied patients treated within 3 hours of onset of ischemic stroke with rt-PA using positron emission tomography to compare Pittsburgh compound B (PiB) (a cerebral β-amyloid ligand) retention in those with and without parenchymal hemorrhage (PH) and normal controls. Neocortical PiB retention was higher among patients with PH compared with patients without PH and normal controls, suggesting underlying CAA as a predisposing factor for rt-PA-related hemorrhage. This finding may provide an impetus for the development of a more practical rapid pretreatment screening technique.
DOI: 10.1002/ana.22072
Type: Journal Article
Subjects: Aged
Benzothiazoles.diagnostic use
Cerebral Amyloid Angiopathy.etiology.radionuclide imaging
Fibrinolytic Agents.adverse effects
Hemorrhage.chemically induced.complications
Magnetic Resonance Imaging.methods
Positron-Emission Tomography.methods
ROC Curve
Retrospective Studies
Stroke.drug therapy
Tissue Plasminogen Activator.adverse effects
Appears in Collections:Journal articles

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