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Title: Gastric leptin: a novel role in cardiovascular regulation.
Austin Authors: Sartor, Daniela M;Verberne, Anthony J M 
Affiliation: Department of Medicine, Austin Health, The University of Melbourne, Heidelberg, Victoria, Australia
Issue Date: 25-Nov-2009
Publication information: American Journal of Physiology. Heart and Circulatory Physiology 2009; 298(2): H406-14
Abstract: Gastric-derived leptin affects satiety and gastrointestinal function via vagal mechanisms and has been shown to interact with the gut hormone cholecystokinin (CCK). CCK selectively inhibits splanchnic sympathetic nerve discharge (SND) and the activity of a subset of presympathetic vasomotor neurons in the rostroventrolateral medulla (RVLM). The present study sought to examine the effects of gastric leptin on arterial pressure (AP), heart rate (HR), SND, and RVLM neuronal activity to determine whether its effects on cardiovascular regulation are dependent on CCK(1) receptors and vagal afferent transmission. To mimic gastric leptin, leptin (15-30 microg/kg) was administered close to the coeliac artery in anesthetized, artificially ventilated Sprague-Dawley rats. Within 5 min, leptin selectively decreased the activity of RVLM neurons also inhibited by CCK (-27 +/- 4%; P < 0.001; n = 15); these inhibitory effects were abolished following administration of the CCK(1) receptor antagonist lorglumide. Leptin significantly decreased AP and HR (-10 +/- 2 mmHg, P < 0.001; and -8 +/- 2 beats/min, P < 0.01; n = 35) compared with saline (-1 +/- 2 mmHg, 3 +/- 2 beats/min; n = 30). In separate experiments, leptin inhibited splanchnic SND compared with saline (-9 +/- 2% vs. 2 +/- 3%, P < 0.01; n = 8). Bilateral cervical vagotomy abolished the sympathoinhibitory, hypotensive, and bradycardic effects of leptin (P < 0.05; n = 6). Our results suggest that gastric leptin may exert acute sympathoinhibitory and cardiovascular effects via vagal transmission and CCK(1) receptor activation and may play a separate role to adipose leptin in short-term cardiovascular regulation.
Gov't Doc #: 19940076
DOI: 10.1152/ajpheart.00997.2009
Type: Journal Article
Subjects: Adipose Tissue.metabolism
Blood Pressure.drug effects.physiology
Cardiovascular Physiological Phenomena
Heart Rate.drug effects.physiology
Hormone Antagonists.pharmacology
Infusions, Intra-Arterial
Infusions, Intravenous
Leptin.administration & dosage.metabolism.pharmacology
Medulla Oblongata.drug effects.physiology
Models, Animal
Proglumide.analogs & derivatives.pharmacology
Rats, Sprague-Dawley
Receptors, Cholecystokinin.antagonists & inhibitors.drug effects.metabolism
Sympathetic Nervous System.drug effects.physiology
Appears in Collections:Journal articles

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