Please use this identifier to cite or link to this item:
Title: Life-threatening sodium valproate overdose: a comparison of two approaches to treatment.
Austin Authors: Licari, Elisa;Calzavacca, Paolo;Warrillow, Stephen J ;Bellomo, Rinaldo 
Affiliation: Department of Intensive Care, Austin Hospital, Melbourne, Australia
Issue Date: 1-Dec-2009
Publication information: Critical Care Medicine; 37(12): 3161-4
Abstract: To describe two identical cases of severe sodium valproate overdose treated with two different approaches.Case report and review of the literature.Two cases of identical life-threatening valproate (VPA) overdose with high VPA blood levels, markedly elevated ammonia levels and coma.One patient was treated with supportive therapy alone until the development of cerebral edema and seizures; the other was treated with immediate extended hemodialysis followed by high-volume hemodiafiltration.The first patient remained critically ill with elevated VPA and ammonia levels until the development of seizures and life-threatening cerebral edema. After the delayed application of hemofiltration, the patient slowly recovered to be discharged from intensive care on day 11. In contrast, the second patient's VPA and ammonia levels rapidly declined with hemodialysis and hemodiafiltration with rapid clinical improvement and intensive care discharge on day 3.In severe VPA overdose, early intervention with blood purification of suitable intensity was associated with a rapid reduction in VPA and ammonia levels and clinical improvement. This improvement was not seen with supportive therapy alone.
Gov't Doc #: 19633542
DOI: 10.1097/CCM.0b013e3181b03245
Journal: Critical Care Medicine
Type: Journal Article
Subjects: Adult
Antimanic Agents.administration & dosage.poisoning
Drug Overdose
Emergency Treatment.methods
Valproic Acid.administration & dosage.poisoning
Appears in Collections:Journal articles

Show full item record

Page view(s)

checked on Jul 18, 2024

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.