Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10861
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLicari, Elisaen
dc.contributor.authorCalzavacca, Paoloen
dc.contributor.authorWarrillow, Stephen Jen
dc.contributor.authorBellomo, Rinaldoen
dc.date.accessioned2015-05-16T00:26:21Z
dc.date.available2015-05-16T00:26:21Z
dc.date.issued2009-12-01en
dc.identifier.citationCritical Care Medicine; 37(12): 3161-4en
dc.identifier.govdoc19633542en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10861en
dc.description.abstractTo describe two identical cases of severe sodium valproate overdose treated with two different approaches.Case report and review of the literature.Two cases of identical life-threatening valproate (VPA) overdose with high VPA blood levels, markedly elevated ammonia levels and coma.One patient was treated with supportive therapy alone until the development of cerebral edema and seizures; the other was treated with immediate extended hemodialysis followed by high-volume hemodiafiltration.The first patient remained critically ill with elevated VPA and ammonia levels until the development of seizures and life-threatening cerebral edema. After the delayed application of hemofiltration, the patient slowly recovered to be discharged from intensive care on day 11. In contrast, the second patient's VPA and ammonia levels rapidly declined with hemodialysis and hemodiafiltration with rapid clinical improvement and intensive care discharge on day 3.In severe VPA overdose, early intervention with blood purification of suitable intensity was associated with a rapid reduction in VPA and ammonia levels and clinical improvement. This improvement was not seen with supportive therapy alone.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAntimanic Agents.administration & dosage.poisoningen
dc.subject.otherDrug Overdoseen
dc.subject.otherEmergency Treatment.methodsen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherPoisoning.therapyen
dc.subject.otherValproic Acid.administration & dosage.poisoningen
dc.titleLife-threatening sodium valproate overdose: a comparison of two approaches to treatment.en
dc.typeJournal Articleen
dc.identifier.journaltitleCritical Care Medicineen
dc.identifier.affiliationDepartment of Intensive Care, Austin Hospital, Melbourne, Australiaen
dc.identifier.doi10.1097/CCM.0b013e3181b03245en
dc.description.pages3161-4en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/19633542en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.deptIntensive Care-
crisitem.author.deptIntensive Care-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

8
checked on Feb 2, 2023

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.