Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10817
Title: Hashimoto encephalopathy and Down syndrome.
Austin Authors: Brodtmann, Amy 
Affiliation: National Stroke Research Institute, Level 1, Neurosciences Building, Austin Health, Heidelberg 3084, Australia
Issue Date: 1-May-2009
Publication information: Archives of Neurology; 66(5): 663-6
Abstract: Hashimoto encephalopathy is a potentially fatal condition associated with a presentation of myoclonus, altered conscious state, strokelike episodes, rapid cognitive decline, and neuropsychiatric symptoms. Both congenital hypothyroidism and acquired hypothyroidism are common in patients with Down syndrome.To describe the presentation of Hashimoto encephalopathy in patients with Down syndrome.Clinical case reports.General neurology unit. Patients Two Down syndrome patients diagnosed as having Hashimoto encephalopathy are described. Intervention High-dose oral corticosteroids.Neurologic examination, electroencephalography, and blood analysis results.Both patients responded to treatment, with a slow return to their premorbid level of function.Hashimoto encephalopathy should be considered in Down syndrome patients with rapidly progressive cognitive decline.
Gov't Doc #: 19433669
URI: http://ahro.austin.org.au/austinjspui/handle/1/10817
DOI: 10.1001/archneurol.2009.45
URL: https://pubmed.ncbi.nlm.nih.gov/19433669
Type: Journal Article
Subjects: Adrenal Cortex Hormones.administration & dosage
Brain.metabolism.pathology.physiopathology
Brain Diseases, Metabolic.drug therapy.genetics.physiopathology
Comorbidity
Disease Progression
Down Syndrome.drug therapy.genetics.physiopathology
Electroencephalography
Female
Genetic Predisposition to Disease
Hashimoto Disease.drug therapy.genetics.physiopathology
Humans
Magnetic Resonance Imaging
Middle Aged
Thyroid Gland.physiopathology.secretion
Thyroid Hormones.metabolism.secretion
Treatment Outcome
Young Adult
Appears in Collections:Journal articles

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