Please use this identifier to cite or link to this item: http://ahro.austin.org.au/austinjspui/handle/1/10656
Title: Low testosterone and anaemia in men with type 2 diabetes.
Authors: Grossmann, Mathis;Panagiotopolous, Sianna;Sharpe, Ken;MacIsaac, Richard J;Clarke, Sophie;Zajac, Jeffrey D;Jerums, George;Thomas, Merlin C
Affiliation: Department of Endocrinology and Medicine, University of Melbourne, Austin Health, Australia. mathisg@unimelb.edu.au
Issue Date: 13-Aug-2008
Citation: Clinical Endocrinology 2008; 70(4): 547-53
Abstract: Anaemia is frequently found in patients with diabetes, in whom it is associated with increased morbidity and mortality. Low testosterone levels are also common in men with type 2 diabetes. We hypothesized that low testosterone levels are also associated with anaemia in men with type 2 diabetes, over the effects of chronic kidney disease.Cross-sectional cohort study, performed in 2005 in a tertiary diabetes clinic. Patients 464 men with type 2 diabetes.Anaemia (haemoglobin (Hb) < 13.7 g/dl in men aged < 60, or < 13.2 g/dl in men aged 60 and older).About 24% of study participants had anaemia, which was associated with the presence and severity of chronic kidney disease, systemic inflammation, increased age, and reduced iron availability. In addition, testosterone levels were independently associated with reduced Hb levels, determining between 6 and 8% of the total variability in raw Hb levels in this population after adjusting for these other factors. Individuals with total testosterone level < 10 nmol/l (43% of the cohort) were more likely to have anaemia (adjusted odds ratio 1.7; 95% CI 1.1-2.8). Similarly, anaemia was twice as common in individuals with a calculated free testosterone of < 0.23 nmol/l (adjusted odds ratio 2.0, 95% CI 1.2-3.1).These findings suggest that testosterone deficiency may contribute to the increased frequency of anaemia in men with type 2 diabetes. However, the appropriate clinical response to testosterone deficiency in anaemic patients remains to be established by prospective clinical trials.
Internal ID Number: 18702678
URI: http://ahro.austin.org.au/austinjspui/handle/1/10656
DOI: 10.1111/j.1365-2265.2008.03357.x
URL: http://www.ncbi.nlm.nih.gov/pubmed/18702678
Type: Journal Article
Subjects: Aged
Anemia.blood.etiology
C-Reactive Protein.metabolism
Chronic Disease
Cohort Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 2.blood.complications
Erythropoietin.blood
Glomerular Filtration Rate
Hemoglobins.metabolism
Humans
Kidney Diseases.blood.complications
Male
Middle Aged
Regression Analysis
Severity of Illness Index
Testosterone.blood
Appears in Collections:Journal articles

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