Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10656
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dc.contributor.authorGrossmann, Mathisen
dc.contributor.authorPanagiotopolous, Siannaen
dc.contributor.authorSharpe, Kenen
dc.contributor.authorMacIsaac, Richard Jen
dc.contributor.authorClarke, Sophieen
dc.contributor.authorZajac, Jeffrey Den
dc.contributor.authorJerums, Georgeen
dc.contributor.authorThomas, Merlin Cen
dc.date.accessioned2015-05-16T00:10:50Z
dc.date.available2015-05-16T00:10:50Z
dc.date.issued2008-08-13en
dc.identifier.citationClinical Endocrinology 2008; 70(4): 547-53en
dc.identifier.govdoc18702678en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10656en
dc.description.abstractAnaemia is frequently found in patients with diabetes, in whom it is associated with increased morbidity and mortality. Low testosterone levels are also common in men with type 2 diabetes. We hypothesized that low testosterone levels are also associated with anaemia in men with type 2 diabetes, over the effects of chronic kidney disease.Cross-sectional cohort study, performed in 2005 in a tertiary diabetes clinic. Patients 464 men with type 2 diabetes.Anaemia (haemoglobin (Hb) < 13.7 g/dl in men aged < 60, or < 13.2 g/dl in men aged 60 and older).About 24% of study participants had anaemia, which was associated with the presence and severity of chronic kidney disease, systemic inflammation, increased age, and reduced iron availability. In addition, testosterone levels were independently associated with reduced Hb levels, determining between 6 and 8% of the total variability in raw Hb levels in this population after adjusting for these other factors. Individuals with total testosterone level < 10 nmol/l (43% of the cohort) were more likely to have anaemia (adjusted odds ratio 1.7; 95% CI 1.1-2.8). Similarly, anaemia was twice as common in individuals with a calculated free testosterone of < 0.23 nmol/l (adjusted odds ratio 2.0, 95% CI 1.2-3.1).These findings suggest that testosterone deficiency may contribute to the increased frequency of anaemia in men with type 2 diabetes. However, the appropriate clinical response to testosterone deficiency in anaemic patients remains to be established by prospective clinical trials.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAnemia.blood.etiologyen
dc.subject.otherC-Reactive Protein.metabolismen
dc.subject.otherChronic Diseaseen
dc.subject.otherCohort Studiesen
dc.subject.otherCross-Sectional Studiesen
dc.subject.otherDiabetes Mellitus, Type 2.blood.complicationsen
dc.subject.otherErythropoietin.blooden
dc.subject.otherGlomerular Filtration Rateen
dc.subject.otherHemoglobins.metabolismen
dc.subject.otherHumansen
dc.subject.otherKidney Diseases.blood.complicationsen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherRegression Analysisen
dc.subject.otherSeverity of Illness Indexen
dc.subject.otherTestosterone.blooden
dc.titleLow testosterone and anaemia in men with type 2 diabetes.en
dc.typeJournal Articleen
dc.identifier.journaltitleClinical Endocrinologyen
dc.identifier.affiliationDepartment of Endocrinology and Medicine, University of Melbourne, Austin Health, Australiaen
dc.identifier.doi10.1111/j.1365-2265.2008.03357.xen
dc.description.pages547-53en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/18702678en
dc.type.austinJournal Articleen
local.name.researcherGrossmann, Mathis
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEndocrinology-
crisitem.author.deptEndocrinology-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptEndocrinology-
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