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Title: ABO blood group and related antigens, natural antibodies and transplantation.
Austin Authors: Milland, Julie;Sandrin, Mauro S 
Affiliation: Department of Surgery (Austin Health), University of Melbourne, Box 5555, Heidelberg 3084, Australia
Issue Date: 1-Dec-2006
Publication information: Tissue Antigens; 68(6): 459-66
Abstract: The current success rate of transplant surgery and immunosuppression has led to a demand for organs that has outstripped the supply. This has required investigation of alternate strategies. Therefore, allotransplantation across the ABO blood group barrier has commenced, and pig-to-human xenotransplantation is under consideration. The first immunological barrier to both these types of transplantation is the prevention of the antibody-mediated rejection. This rejection is a result of natural preformed antibodies circulating in the serum of the recipient binding to either ABO (for allo) or alpha-galactose (alpha-Gal) (for xeno) antigens expressed on the donor tissue. These antibodies recognise antigens that are, in both cases, carbohydrate molecules with the characteristic feature that the nonreducing terminal carbohydrate is either a Gal or N-acetlygalactosamine residue in an alpha1,3 linkage. These epitopes are synthesised by closely related members of a single family of glycosyltransferases. This review discusses the carbohydrate antigens, the enzymes involved in their synthesis and the consequences of natural antibodies binding these antigens.
Gov't Doc #: 17176435
DOI: 10.1111/j.1399-0039.2006.00721.x
Journal: Tissue antigens
Type: Journal Article
Subjects: ABO Blood-Group System.chemistry.immunology
Amino Acid Sequence
Graft Rejection.immunology
Molecular Sequence Data
Sequence Alignment
Transplantation, Heterologous
Transplantation, Homologous
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