Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10289
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dc.contributor.authorMilland, Julieen
dc.contributor.authorSandrin, Mauro Sen
dc.date.accessioned2015-05-15T23:41:51Z
dc.date.available2015-05-15T23:41:51Z
dc.date.issued2006-12-01en
dc.identifier.citationTissue Antigens; 68(6): 459-66en
dc.identifier.govdoc17176435en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10289en
dc.description.abstractThe current success rate of transplant surgery and immunosuppression has led to a demand for organs that has outstripped the supply. This has required investigation of alternate strategies. Therefore, allotransplantation across the ABO blood group barrier has commenced, and pig-to-human xenotransplantation is under consideration. The first immunological barrier to both these types of transplantation is the prevention of the antibody-mediated rejection. This rejection is a result of natural preformed antibodies circulating in the serum of the recipient binding to either ABO (for allo) or alpha-galactose (alpha-Gal) (for xeno) antigens expressed on the donor tissue. These antibodies recognise antigens that are, in both cases, carbohydrate molecules with the characteristic feature that the nonreducing terminal carbohydrate is either a Gal or N-acetlygalactosamine residue in an alpha1,3 linkage. These epitopes are synthesised by closely related members of a single family of glycosyltransferases. This review discusses the carbohydrate antigens, the enzymes involved in their synthesis and the consequences of natural antibodies binding these antigens.en
dc.language.isoenen
dc.subject.otherABO Blood-Group System.chemistry.immunologyen
dc.subject.otherAmino Acid Sequenceen
dc.subject.otherAnimalsen
dc.subject.otherAntibodies.immunologyen
dc.subject.otherCarbohydrates.immunologyen
dc.subject.otherEpitopes.immunologyen
dc.subject.otherGalactosyltransferases.analysis.chemistryen
dc.subject.otherGraft Rejection.immunologyen
dc.subject.otherHumansen
dc.subject.otherMolecular Sequence Dataen
dc.subject.otherSequence Alignmenten
dc.subject.otherSwineen
dc.subject.otherTransplantation, Heterologousen
dc.subject.otherTransplantation, Homologousen
dc.titleABO blood group and related antigens, natural antibodies and transplantation.en
dc.typeJournal Articleen
dc.identifier.journaltitleTissue antigensen
dc.identifier.affiliationDepartment of Surgery (Austin Health), University of Melbourne, Box 5555, Heidelberg 3084, Australiaen
dc.identifier.doi10.1111/j.1399-0039.2006.00721.xen
dc.description.pages459-66en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/17176435en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
crisitem.author.deptSurgery (University of Melbourne)-
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