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Title: The inhibitory effect of [D-Arg1,D-Phe,D-Try7,9,Leu11] substance P on endothelin-1 binding sites in rat cardiac membranes.
Austin Authors: Gu, X H;Casley, David J;Nayler, W G
Affiliation: Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg VIC Australia
Issue Date: 30-Aug-1991
Publication information: Biochemical and Biophysical Research Communications; 179(1): 130-3
Abstract: The specific binding of [125I]ET-1 to rat cardiac membrane fragments was inhibited by [D-Arg1,D-Phe, D-Try7,9,Leu11] substance P [substance P(D)], a potent bombesin antagonist. This inhibitory effect required high concentrations (greater than 3X10(-6)M) of substance P(D) and was accompanied by a steep increase in non-specific binding, and not a decrease in total binding. Such results indicate that substance P(D) does not competitively inhibit the specific binding of [125I]ET-1 to rat cardiac membrane fragments.
Gov't Doc #: 1715689
Journal: Biochemical and biophysical research communications
Type: Journal Article
Subjects: Animals
Binding Sites
Bombesin.antagonists & inhibitors
Cell Membrane.metabolism
Heart Ventricles
Rats, Inbred Strains
Receptors, Cell Surface.drug effects.metabolism
Receptors, Endothelin
Substance P.analogs & derivatives.pharmacology
Appears in Collections:Journal articles

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