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https://ahro.austin.org.au/austinjspui/handle/1/10282| Title: | The inhibitory effect of [D-Arg1,D-Phe,D-Try7,9,Leu11] substance P on endothelin-1 binding sites in rat cardiac membranes. | Austin Authors: | Gu, X H;Casley, David J;Nayler, W G | Affiliation: | Department of Medicine, University of Melbourne, Austin Hospital, Heidelberg VIC Australia | Issue Date: | 30-Aug-1991 | Publication information: | Biochemical and Biophysical Research Communications; 179(1): 130-3 | Abstract: | The specific binding of [125I]ET-1 to rat cardiac membrane fragments was inhibited by [D-Arg1,D-Phe, D-Try7,9,Leu11] substance P [substance P(D)], a potent bombesin antagonist. This inhibitory effect required high concentrations (greater than 3X10(-6)M) of substance P(D) and was accompanied by a steep increase in non-specific binding, and not a decrease in total binding. Such results indicate that substance P(D) does not competitively inhibit the specific binding of [125I]ET-1 to rat cardiac membrane fragments. | Gov't Doc #: | 1715689 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/10282 | Journal: | Biochemical and biophysical research communications | URL: | https://pubmed.ncbi.nlm.nih.gov/1715689 | Type: | Journal Article | Subjects: | Animals Binding Sites Bombesin.antagonists & inhibitors Cell Membrane.metabolism Endothelins.metabolism Heart Ventricles Kinetics Myocardium.metabolism Rats Rats, Inbred Strains Receptors, Cell Surface.drug effects.metabolism Receptors, Endothelin Substance P.analogs & derivatives.pharmacology |
| Appears in Collections: | Journal articles |
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