1. AHRO : Austin Health Research Online
  2. Austin Health research
  3. Journal articles
Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10282
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGu, X Hen
dc.contributor.authorCasley, David Jen
dc.contributor.authorNayler, W Gen
dc.date.accessioned2015-05-15T23:41:19Z
dc.date.available2015-05-15T23:41:19Z
dc.date.issued1991-08-30en
dc.identifier.citationBiochemical and Biophysical Research Communications; 179(1): 130-3en
dc.identifier.govdoc1715689en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10282en
dc.description.abstractThe specific binding of [125I]ET-1 to rat cardiac membrane fragments was inhibited by [D-Arg1,D-Phe, D-Try7,9,Leu11] substance P [substance P(D)], a potent bombesin antagonist. This inhibitory effect required high concentrations (greater than 3X10(-6)M) of substance P(D) and was accompanied by a steep increase in non-specific binding, and not a decrease in total binding. Such results indicate that substance P(D) does not competitively inhibit the specific binding of [125I]ET-1 to rat cardiac membrane fragments.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherBinding Sitesen
dc.subject.otherBombesin.antagonists & inhibitorsen
dc.subject.otherCell Membrane.metabolismen
dc.subject.otherEndothelins.metabolismen
dc.subject.otherHeart Ventriclesen
dc.subject.otherKineticsen
dc.subject.otherMyocardium.metabolismen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherReceptors, Cell Surface.drug effects.metabolismen
dc.subject.otherReceptors, Endothelinen
dc.subject.otherSubstance P.analogs & derivatives.pharmacologyen
dc.titleThe inhibitory effect of [D-Arg1,D-Phe,D-Try7,9,Leu11] substance P on endothelin-1 binding sites in rat cardiac membranes.en
dc.typeJournal Articleen
dc.identifier.journaltitleBiochemical and biophysical research communicationsen
dc.identifier.affiliationDepartment of Medicine, University of Melbourne, Austin Hospital, Heidelberg VIC Australiaen
dc.description.pages130-3en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1715689en
dc.type.austinJournal Articleen
item.grantfulltextnone-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

8
checked on Aug 30, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.