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Title: Lack of correlation of hypoxic cell fraction and angiogenesis with glucose metabolic rate in non-small cell lung cancer assessed by 18F-Fluoromisonidazole and 18F-FDG PET.
Austin Authors: Cherk, Martin H;Foo, Serene S;Poon, Aurora M T ;Knight, Simon R ;Murone, Carmel ;Papenfuss, Anthony T;Sachinidis, John I;Saunder, Timothy H C;O'Keefe, Graeme J;Scott, Andrew M 
Affiliation: Centre for PET, Austin Hospital, Heidelberg, Victoria, Australia
Issue Date: 1-Dec-2006
Publication information: Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine; 47(12): 1921-6
Abstract: PET offers a noninvasive means to assess neoplasms, in view of its sensitivity and accuracy in staging tumors and potentially in monitoring treatment response. The aim of this study was to evaluate newly diagnosed non-small cell lung cancer (NSCLC) for the presence of hypoxia, as indicated by the uptake of (18)F-Fluoromisonidazole ((18)F-FMISO), and to examine the relationship of hypoxia to the uptake of (18)F-FDG, microvessel density, and other molecular markers of hypoxia.Twenty-one patients with suspected or biopsy-proven NSCLC were enrolled prospectively in this study. All patients had PET studies with (18)F-FMISO and (18)F-FDG. Seventeen patients subsequently underwent surgery, with analysis performed for tumor markers of angiogenesis and hypoxia.In the 17 patients with resectable NSCLC (13 men, 4 women; age range, 51-77 y), the mean (18)F-FMISO uptake in tumor was significantly lower than that of (18)F-FDG uptake (P < 0.0001) and showed no correlation with (18)F-FDG uptake (r = 0.26). The mean (95% confidence interval [CI]) (18)F-FMISO SUV(max) (maximum standardized uptake value) was 1.20 [0.95-1.45] compared with the mean [95% CI] (18)F-FDG SUV(max) of 5.99 [4.62-7.35]. The correlation between (18)F-FMISO uptake, (18)F-FDG uptake, and tumor markers of hypoxia and angiogenesis was poor. A weakly positive correlation between (18)F-FMISO and (18)F-FDG uptake and Ki67 was found.The hypoxic cell fraction of primary NSCLC is consistently low, and there is no significant correlation in NSCLC between hypoxia and glucose metabolism in NSCLC assessed by (18)F-FDG. These findings have direct implications in understanding the role of angiogenesis and hypoxia in NSCLC biology.
Gov't Doc #: 17138734
Journal: Journal of Nuclear Medicine
Type: Journal Article
Subjects: Aged
Carcinoma, Non-Small-Cell Lung.metabolism.radionuclide imaging
Cell Hypoxia
Fluorodeoxyglucose F18.diagnostic use.pharmacokinetics
Lung Neoplasms.metabolism.radionuclide imaging
Metabolic Clearance Rate
Middle Aged
Misonidazole.analogs & derivatives.diagnostic use.pharmacokinetics
Neovascularization, Pathologic.metabolism.radionuclide imaging
Radiopharmaceuticals.diagnostic use.pharmacokinetics
Statistics as Topic
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