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Title: Relationship between language lateralization and handedness in left-hemispheric partial epilepsy.
Austin Authors: Sveller, C;Briellmann, Regula S;Saling, Michael M ;Lillywhite, L;Abbott, David F ;Masterton, Richard A J;Jackson, Graeme D 
Affiliation: Brain Research Institute, Neurosciences Bldg., Austin Health, Heidelberg West, Victoria, 3081, Australia
Issue Date: 28-Nov-2006
Publication information: Neurology; 67(10): 1813-7
Abstract: To investigate the relationship between language lateralization and handedness in patients with epilepsy and a left-sided seizure focus and in healthy control subjects.We recruited a consecutive series of 74 patients and 70 control subjects. Functional MRI, using a noun-verb generation task, was performed to establish the language laterality index (LI). Handedness was quantified using the Edinburgh Handedness Inventory.Patients showed a shift toward atypical language lateralization (0.43 +/- 0.47; controls 0.57 +/- 034; p < or = 0.05) and left-handedness (55 +/- 57; controls 74 +/- 39; p < or = 0.05). The LI and handedness were correlated in patients (r = 0.54; F = 25.9; p < 0.001) but not in control subjects (r = 0.1; F = 0.64; NS). A combination of left-handedness and atypical LI was more frequent in patients (12%) than control subjects (0%; p < or = 0.05). Crossed hemispheric specialization (e.g., right-handedness associated with atypical LI) was equally frequent in patients (20%) and control subjects (16%; NS).In epilepsy patients with a left-sided seizure focus, language lateralization is correlated to handedness. The increased frequency of left-handedness and associated atypical language lateralization is most likely related to the left-hemispheric seizure focus, influencing hemispheric specialization for both domains.
Gov't Doc #: 17130414
DOI: 10.1212/01.wnl.0000244465.74707.42
Journal: Neurology
Type: Journal Article
Subjects: Adolescent
Brain Mapping
Cerebral Cortex.pathology.physiopathology.radionuclide imaging
Corpus Callosum.physiology
Epilepsies, Partial.diagnosis.physiopathology
Functional Laterality.physiology
Language Tests
Magnetic Resonance Imaging
Middle Aged
Neural Pathways.pathology.physiopathology.radionuclide imaging
Positron-Emission Tomography
Tomography, Emission-Computed, Single-Photon
Verbal Behavior.physiology
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