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|Title:||Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin.||Austin Authors:||McIntyre, I M;Norman, Trevor R||Affiliation:||Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia||Issue Date:||16-May-1990||Publication information:||Journal of Neural Transmission. General Section; 79(1-2): 35-40||Abstract:||A study of the acute effects of isatin, an endogenous MAO inhibitor related to tribulin, on rat brain serotonergic function was undertaken. A single dose of isatin significantly increased 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations. Synaptosomal 5-HT uptake was unaffected but there was a trend for the number of 3H-ketanserin binding sites was to be decreased. The results of the study are discussed in terms of the relationship of isatin to tribulin and their possible causal role in stress.||Gov't Doc #:||1688707||URI:||http://ahro.austin.org.au/austinjspui/handle/1/10211||URL:||https://pubmed.ncbi.nlm.nih.gov/1688707||Type:||Journal Article||Subjects:||Animals
Cerebral Cortex.drug effects.metabolism
Monoamine Oxidase Inhibitors.metabolism.pharmacology
Rats, Inbred Strains
|Appears in Collections:||Journal articles|
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