Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/10211| Title: | Serotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin. | Austin Authors: | McIntyre, I M;Norman, Trevor R | Affiliation: | Department of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 16-May-1990 | Publication information: | Journal of Neural Transmission. General Section; 79(1-2): 35-40 | Abstract: | A study of the acute effects of isatin, an endogenous MAO inhibitor related to tribulin, on rat brain serotonergic function was undertaken. A single dose of isatin significantly increased 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations. Synaptosomal 5-HT uptake was unaffected but there was a trend for the number of 3H-ketanserin binding sites was to be decreased. The results of the study are discussed in terms of the relationship of isatin to tribulin and their possible causal role in stress. | Gov't Doc #: | 1688707 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/10211 | Journal: | Journal of neural transmission. General section | URL: | https://pubmed.ncbi.nlm.nih.gov/1688707 | Type: | Journal Article | Subjects: | Animals Cerebral Cortex.drug effects.metabolism Hydroxyindoleacetic Acid.metabolism Hypothalamus.drug effects.metabolism Indoles.pharmacology Isatin.pharmacology Ketanserin.metabolism Male Monoamine Oxidase Inhibitors.metabolism.pharmacology Rats Rats, Inbred Strains Serotonin.metabolism.pharmacokinetics Synaptosomes.metabolism |
| Appears in Collections: | Journal articles |
Show full item record
Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.