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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10211
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dc.contributor.authorMcIntyre, I Men
dc.contributor.authorNorman, Trevor Ren
dc.date.accessioned2015-05-15T23:35:23Z
dc.date.available2015-05-15T23:35:23Z
dc.date.issued1990-05-16en
dc.identifier.citationJournal of Neural Transmission. General Section; 79(1-2): 35-40en
dc.identifier.govdoc1688707en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10211en
dc.description.abstractA study of the acute effects of isatin, an endogenous MAO inhibitor related to tribulin, on rat brain serotonergic function was undertaken. A single dose of isatin significantly increased 5-HT concentrations in the hypothalamus and cortex but did not significantly alter 5-HIAA concentrations. Synaptosomal 5-HT uptake was unaffected but there was a trend for the number of 3H-ketanserin binding sites was to be decreased. The results of the study are discussed in terms of the relationship of isatin to tribulin and their possible causal role in stress.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherCerebral Cortex.drug effects.metabolismen
dc.subject.otherHydroxyindoleacetic Acid.metabolismen
dc.subject.otherHypothalamus.drug effects.metabolismen
dc.subject.otherIndoles.pharmacologyen
dc.subject.otherIsatin.pharmacologyen
dc.subject.otherKetanserin.metabolismen
dc.subject.otherMaleen
dc.subject.otherMonoamine Oxidase Inhibitors.metabolism.pharmacologyen
dc.subject.otherRatsen
dc.subject.otherRats, Inbred Strainsen
dc.subject.otherSerotonin.metabolism.pharmacokineticsen
dc.subject.otherSynaptosomes.metabolismen
dc.titleSerotonergic effects of isatin: an endogenous MAO inhibitor related to tribulin.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of neural transmission. General sectionen
dc.identifier.affiliationDepartment of Psychiatry, University of Melbourne, Austin Hospital, Heidelberg, Victoria, Australiaen
dc.description.pages35-40en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1688707en
dc.type.austinJournal Articleen
local.name.researcherNorman, Trevor R
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptPsychiatry (University of Melbourne)-
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