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Title: Persisting concentrating and second gas effects on oxygenation during N2O anaesthesia.
Austin Authors: Peyton, Philip J ;Stuart-Andrews, C;Deo, K;Strahan, F;Robinson, Gavin J B;Thompson, Bruce R;Pierce, Robert J
Affiliation: Joint Director of Research, Department of Anaesthesia, Austin Hospital, Heidelberg, 3084, Melbourne, Australia
Issue Date: 1-Apr-2006
Publication information: Anaesthesia; 61(4): 322-9
Abstract: Theoretical modelling predicts that the concentrating effect of nitrous oxide (N2O) uptake on alveolar oxygenation is a persisting phenomenon at typical levels of ventilation - perfusion (V/Q) inhomogeneity under anaesthesia. We sought clinical confirmation of this in 20 anaesthetised patients. Arterial oxygen pressure (P(aO2)) was measured after a minimum of 30 min of relaxant general anaesthesia with an inspired oxygen (F(I O2)) of 30%. Patients were randomly allocated to two groups. The intervention group had N2O introduced following baseline blood gas measurements, and the control group continued breathing an identical F(I O2) in nitrogen (N2). The primary outcome variable was change in P(aO2). Mean (SD) in P(aO2) was increased by 1.80 (1.80) kPa after receiving a mean of 47.5 min of N2O compared with baseline conditions breathing O2/N2 (p = 0.01). This change was significantly greater (p = 0.03) than that in the control group: + 0.09 (1.37) kPa, p = 0.83 and confirms the presence of significant persisting concentrating and second gas effects.
Gov't Doc #: 16548949
DOI: 10.1111/j.1365-2044.2006.04579.x
Type: Journal Article
Subjects: Aged
Aged, 80 and over
Analysis of Variance
Anesthesia, Inhalation.methods
Anesthetics, Inhalation.pharmacology
Internal Mammary-Coronary Artery Anastomosis
Intraoperative Period
Middle Aged
Nitrous Oxide.pharmacology
Oxygen Consumption.drug effects
Partial Pressure
Pulmonary Gas Exchange.drug effects
Appears in Collections:Journal articles

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