Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10124
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dc.contributor.authorPeyton, Philip Jen
dc.contributor.authorStuart-Andrews, Cen
dc.contributor.authorDeo, Ken
dc.contributor.authorStrahan, Fen
dc.contributor.authorRobinson, Gavin J Ben
dc.contributor.authorThompson, Bruce Ren
dc.contributor.authorPierce, Robert Jen
dc.date.accessioned2015-05-15T23:28:34Z
dc.date.available2015-05-15T23:28:34Z
dc.date.issued2006-04-01en
dc.identifier.citationAnaesthesia; 61(4): 322-9en
dc.identifier.govdoc16548949en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/10124en
dc.description.abstractTheoretical modelling predicts that the concentrating effect of nitrous oxide (N2O) uptake on alveolar oxygenation is a persisting phenomenon at typical levels of ventilation - perfusion (V/Q) inhomogeneity under anaesthesia. We sought clinical confirmation of this in 20 anaesthetised patients. Arterial oxygen pressure (P(aO2)) was measured after a minimum of 30 min of relaxant general anaesthesia with an inspired oxygen (F(I O2)) of 30%. Patients were randomly allocated to two groups. The intervention group had N2O introduced following baseline blood gas measurements, and the control group continued breathing an identical F(I O2) in nitrogen (N2). The primary outcome variable was change in P(aO2). Mean (SD) in P(aO2) was increased by 1.80 (1.80) kPa after receiving a mean of 47.5 min of N2O compared with baseline conditions breathing O2/N2 (p = 0.01). This change was significantly greater (p = 0.03) than that in the control group: + 0.09 (1.37) kPa, p = 0.83 and confirms the presence of significant persisting concentrating and second gas effects.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAged, 80 and overen
dc.subject.otherAnalysis of Varianceen
dc.subject.otherAnesthesia, Inhalation.methodsen
dc.subject.otherAnesthetics, Inhalation.pharmacologyen
dc.subject.otherHumansen
dc.subject.otherInternal Mammary-Coronary Artery Anastomosisen
dc.subject.otherIntraoperative Perioden
dc.subject.otherMiddle Ageden
dc.subject.otherNitrous Oxide.pharmacologyen
dc.subject.otherOxygen.blooden
dc.subject.otherOxygen Consumption.drug effectsen
dc.subject.otherPartial Pressureen
dc.subject.otherPulmonary Gas Exchange.drug effectsen
dc.titlePersisting concentrating and second gas effects on oxygenation during N2O anaesthesia.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnaesthesiaen
dc.identifier.affiliationJoint Director of Research, Department of Anaesthesia, Austin Hospital, Heidelberg, 3084, Melbourne, Australiaen
dc.identifier.doi10.1111/j.1365-2044.2006.04579.xen
dc.description.pages322-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16548949en
dc.type.austinJournal Articleen
local.name.researcherPeyton, Philip J
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptAnaesthesia-
crisitem.author.deptInstitute for Breathing and Sleep-
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