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Title: Functional connectivity networks are disrupted in left temporal lobe epilepsy.
Austin Authors: Waites, Anthony B;Briellmann, Regula S;Saling, Michael M ;Abbott, David F ;Jackson, Graeme D 
Affiliation: Brain Research Institute, Austin Health, Heidelberg West, Victoria, Australia
Issue Date: 1-Feb-2006
Publication information: Annals of Neurology; 59(2): 335-43
Abstract: Functional connectivity maps the distributed network of brain regions fluctuating synchronously during a continuous brain state. This study sought to investigate whether patients with left temporal lobe epilepsy (TLE) differ from controls in their resting-state functional connectivity between typical language regions.We studied 17 patients with left TLE, together with eight healthy controls, using seeded functional connectivity. Seed regions were defined using the regions of maximal activation and deactivation during a language functional magnetic resonance imaging (fMRI) task in a separate cohort of 30 controls.Language fMRI produced the expected activation pattern, which was not different between patients and controls. However, functional connectivity between language areas during rest was markedly different; whereas controls showed connectivity between each of the seed areas and the majority of the language areas, patients showed connectivity only with a few areas, particularly the seed area itself. This difference was significant in the direct comparison of patients and control connectivity maps.We suggest that this reduced connectivity in left temporal lobe epilepsy may reflect a disturbance of the language network during resting state in patients and may be related to subtle language difficulties in this patient population.
Gov't Doc #: 16404743
DOI: 10.1002/ana.20733
Journal: Annals of Neurology
Type: Journal Article
Subjects: Adult
Brain Mapping
Epilepsy, Temporal Lobe.pathology.physiopathology
Functional Laterality.physiology
Image Processing, Computer-Assisted.methods
Magnetic Resonance Imaging.methods
Middle Aged
Nerve Net.blood supply.pathology.physiopathology
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