Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10070
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dc.contributor.authorWaites, Anthony Ben
dc.contributor.authorBriellmann, Regula Sen
dc.contributor.authorSaling, Michael Men
dc.contributor.authorAbbott, David Fen
dc.contributor.authorJackson, Graeme Den
dc.date.accessioned2015-05-15T23:24:27Z
dc.date.available2015-05-15T23:24:27Z
dc.date.issued2006-02-01en
dc.identifier.citationAnnals of Neurology; 59(2): 335-43en
dc.identifier.govdoc16404743en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10070en
dc.description.abstractFunctional connectivity maps the distributed network of brain regions fluctuating synchronously during a continuous brain state. This study sought to investigate whether patients with left temporal lobe epilepsy (TLE) differ from controls in their resting-state functional connectivity between typical language regions.We studied 17 patients with left TLE, together with eight healthy controls, using seeded functional connectivity. Seed regions were defined using the regions of maximal activation and deactivation during a language functional magnetic resonance imaging (fMRI) task in a separate cohort of 30 controls.Language fMRI produced the expected activation pattern, which was not different between patients and controls. However, functional connectivity between language areas during rest was markedly different; whereas controls showed connectivity between each of the seed areas and the majority of the language areas, patients showed connectivity only with a few areas, particularly the seed area itself. This difference was significant in the direct comparison of patients and control connectivity maps.We suggest that this reduced connectivity in left temporal lobe epilepsy may reflect a disturbance of the language network during resting state in patients and may be related to subtle language difficulties in this patient population.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherBrain Mappingen
dc.subject.otherEpilepsy, Temporal Lobe.pathology.physiopathologyen
dc.subject.otherFemaleen
dc.subject.otherFunctional Laterality.physiologyen
dc.subject.otherHumansen
dc.subject.otherImage Processing, Computer-Assisted.methodsen
dc.subject.otherLanguageen
dc.subject.otherMagnetic Resonance Imaging.methodsen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherNerve Net.blood supply.pathology.physiopathologyen
dc.subject.otherOxygen.blooden
dc.titleFunctional connectivity networks are disrupted in left temporal lobe epilepsy.en
dc.typeJournal Articleen
dc.identifier.journaltitleAnnals of Neurologyen
dc.identifier.affiliationBrain Research Institute, Austin Health, Heidelberg West, Victoria, Australiaen
dc.identifier.doi10.1002/ana.20733en
dc.description.pages335-43en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16404743en
dc.type.austinJournal Articleen
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptClinical Neuropsychology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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