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Title: | Calcium, calcium antagonism, atherosclerosis, and ischemia. | Austin Authors: | Nayler, W G | Affiliation: | Department of Medicine, Austin Hospital, Heidelberg, Victoria, Australia | Issue Date: | 16-May-1992 | Publication information: | Journal of Cardiovascular Pharmacology; 19 Suppl 2(): S17-21 | Abstract: | Calcium is a ubiquitous cation involved in a wide variety of physiological processes. Normally, cytosolic calcium is maintained within narrow limits but under certain conditions the levels rise--either because of excess calcium entry, internal release, or failure of the extrusion mechanisms. Such conditions include hypertension and myocardial ischemia. Calcium ions are also involved in the formation of atherosclerotic lesions. Hypertension, ischemic heart disease, and atherosclerosis are all amenable to calcium antagonist therapy. The efficacy of this class of drugs in the management of such a wide spectrum of disorders is in accord with the central role played by calcium in the etiology of these disorders. To some extent, however, the disorders are interrelated, with hypertension being a major risk factors for ischemic heart disease and atherosclerosis. | Gov't Doc #: | 1377299 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/9585 | Journal: | Journal of Cardiovascular Pharmacology | URL: | https://pubmed.ncbi.nlm.nih.gov/1377299 | Type: | Journal Article | Subjects: | Animals Arteriosclerosis.drug therapy.prevention & control Calcium.metabolism Coronary Disease.drug therapy.metabolism Cytosol.drug effects.metabolism Humans Hypercholesterolemia.drug therapy Hypertension.drug therapy.physiopathology Male Nifedipine.therapeutic use Nitrendipine.therapeutic use Rabbits Rats Rats, Inbred SHR Rats, Inbred WKY |
Appears in Collections: | Journal articles |
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